Journal of Endodontics
Volume 33, Issue 11 , Pages 1309-1312 , November 2007

Proinflammatory Cytokine Expression in Cyclooxygenase-2–deficient Primary Osteoblasts

  • Jianing He, DMD, PhD

      Affiliations

    • Department of Endodontics, Baylor College of Dentistry, The Texas A&M University Health Science Center, Dallas, Texas
    • Corresponding Author InformationAddress requests for reprints to Dr Jianing He, Department of Endodontics, Baylor College of Dentistry, 3302 Gaston Avenue, Dallas, TX 75246.
  • ,
  • Rosamond Tomlinson, BS

      Affiliations

    • Department of Endodontics, Baylor College of Dentistry, The Texas A&M University Health Science Center, Dallas, Texas
  • ,
  • David Coon, DDS

      Affiliations

    • Department of Endodontics, Baylor College of Dentistry, The Texas A&M University Health Science Center, Dallas, Texas
  • ,
  • Ajay Gulati, BDS, MSc

      Affiliations

    • Department of Endodontics, Baylor College of Dentistry, The Texas A&M University Health Science Center, Dallas, Texas
  • ,
  • Cameron Cowan, BS

      Affiliations

    • Department of Biomedical Sciences, Baylor College of Dentistry, The Texas A&M University Health Science Center, Dallas, Texas.

References 

  1. Takahashi K. Microbiological, pathological, inflammatory, immunological and molecular biological aspects of periradicular disease. Int Endod J. 1998;31:311–325
  2. Fabricius L, Dahlen G, Holm SE, Moller AJ. Influence of combinations of oral bacteria on periapical tissues of monkeys. Scand J Dent Res. 1982;90:200–206
  3. Hong CY, Lin SK, Kok SH, et al. The role of lipopolysaccharide in infectious bone resorption of periapical lesion. J Oral Pathol Med. 2004;33:162–169
  4. Jiang J, Li H, Fahid FS, et al. Quantitative analysis of osteoclast-specific gene markers stimulated by lipopolysaccharide. J Endod. 2006;32:742–746
  5. Zou W, Bar-Shavit Z. Dual modulation of osteoclast differentiation by lipopolysaccharide. J Bone Miner Res. 2002;17:1211–1218
  6. Bilezikian JP, Rodan GA. Principles of Bone Biology. San Diego: Academic Press; 2002;
  7. Fung HB, Kirschenbaum HL. Selective cyclooxygenase-2 inhibitors for the treatment of arthritis. Clin Ther. 1999;21:1131–1157
  8. Huang FM, Chou MY, Chang YC. Induction of cyclooxygenase-2 mRNA and protein expression by epoxy resin and zinc oxide-eugenol based root canal sealers in human osteoblastic cells. Biomaterials. 2003;24:1869–1875
  9. Chandrasekharan NV, Dai H, Roos KL, et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci U S A. 2002;99:13926–13931
  10. McNicholas S, Torabinejad M, Blankenship J, Bakland L. The concentration of prostaglandin E2 in human periradicular lesions. J Endod. 1991;17:97–100
  11. Wang CY, Stashenko P. Characterization of bone-resorbing activity in human periapical lesions. J Endod. 1993;19:107–111
  12. Wang CY, Tani-Ishii N, Stashenko P. Bone-resorptive cytokine gene expression in periapical lesions in the rat. Oral Microbiol Immunol. 1997;12:65–71
  13. Takayama S, Miki Y, Shimauchi H, Okada H. Relationship between prostaglandin E2 concentrations in periapical exudates from root canals and clinical findings of periapical periodontitis. J Endod. 1996;22:677–680
  14. Shimauchi H, Takayama S, Miki Y, Okada H. The change of periapical exudate prostaglandin E2 levels during root canal treatment. J Endod. 1997;23:755–758
  15. Oguntebi BR, Barker BF, Anderson DM, Sakumura J. The effect of indomethacin on experimental dental periapical lesions in rats. J Endod. 1989;15:117–121
  16. Gopikrishna V, Parameswaran A. Effectiveness of prophylactic use of rofecoxib in comparison with ibuprofen on postendodontic pain. J Endod. 2003;29:62–64
  17. Stashenko P, Wang CY, Tani-Ishii N, Yu SM. Pathogenesis of induced rat periapical lesions. Oral Surg Oral Med Oral Pathol. 1994;78:494–502
  18. Dinchuk JE, Car BD, Focht RJ, et al. Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II. Nature. 1995;378:406–409
  19. Lim H, Paria BC, Das SK, et al. Multiple female reproductive failures in cyclooxygenase 2-deficient mice. Cell. 1997;91:197–208
  20. Coon D, Gulati A, Cowan C, He J. The role of cyclooxygenase-2 (COX-2) in inflammatory bone resorption. J Endod. 2007;33:432–436
  21. Kida Y, Kobayashi M, Suzuki T, et al. Interleukin-1 stimulates cytokines, prostaglandin E2 and matrix metalloproteinase-1 production via activation of MAPK/AP-1 and NF-kappaB in human gingival fibroblasts. Cytokine. 2005;29:159–168
  22. Chang MC, Chen YJ, Tai TF, et al. Cytokine-induced prostaglandin E2 production and cyclooxygenase-2 expression in dental pulp cells: downstream calcium signalling via activation of prostaglandin EP receptor. Int Endod J. 2006;39:819–826
  23. Lin SK, Kuo MY, Wang JS, et al. Differential regulation of interleukin-6 and inducible cyclooxygenase gene expression by cytokines through prostaglandin-dependent and -independent mechanisms in human dental pulp fibroblasts. J Endod. 2002;28:197–201
  24. Park YG, Kang SK, Kim WJ, Lee YC, Kim CH. Effects of TGF-beta, TNF-alpha, IL-beta and IL-6 alone or in combination, and tyrosine kinase inhibitor on cyclooxygenase expression, prostaglandin E2 production and bone resorption in mouse calvarial bone cells. Int J Biochem Cell Biol. 2004;36:2270–2280
  25. Noguchi K, Miyauchi M, Oka H, Komaki M, Somerman MJ, Takata T. Cyclooxygenase-2-dependent prostaglandin E(2) upregulates interleukin (IL)-1alpha-induced IL-6 generation in mouse cementoblasts. J Periodontol. 2007;78:135–140
  26. Igarashi K, Woo JT, Stern PH. Effects of a selective cyclooxygenase-2 inhibitor, celecoxib, on bone resorption and osteoclastogenesis in vitro. Biochem Pharmacol. 2002;63:523–532
  27. Koh ET, McDonald F, Pitt Ford TR, Torabinejad M. Cellular response to mineral trioxide aggregate. J Endod. 1998;24:543–547
  28. Haglund R, He J, Jarvis J, Safavi KE, Spangberg LS, Zhu Q. Effects of root-end filling materials on fibroblasts and macrophages in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;95:739–745
  29. Pinheiro RM, Calixto JB. Effect of the selective COX-2 inhibitors, celecoxib and rofecoxib in rat acute models of inflammation. Inflamm Res. 2002;51:603–610
  30. Reikeras O, Sun J, Wang JE, Aasen AO. Postoperative serum attenuates LPS-induced release of TNF-alpha in orthopaedic surgery. J Orthop Res. 2007;(Epub ahead of print)
  31. Ejima K, Layne MD, Carvajal IM, Kritek PA, Baron RM, Chen Y-H, et al. Cyclooxygenase-2 deficient mice are resistant to endotoxin-induced inflammation and death. The FASEB Journal. 2003;17:1325–1327

PII: S0099-2399(07)00756-X

doi: 10.1016/j.joen.2007.08.001

Journal of Endodontics
Volume 33, Issue 11 , Pages 1309-1312 , November 2007