Journal of Endodontics
Volume 31, Issue 12 , Pages 860-862 , December 2005

The Upregulation of Matrix Metalloproteinase-9 in Inflamed Human Dental Pulps

  • Chung-Hung Tsai, DDS, MPH

      Affiliations

    • Department of Pathology;, Chung Shan Medical University Hospital, Taichung, Taiwan.
    • ,
  • Yi-Juai Chen, DDS, MSD

      Affiliations

    • Department of Oral Surgery;, Chung Shan Medical University Hospital, Taichung, Taiwan.
    • ,
  • Fu-Mei Huang, DDS, MS

      Affiliations

    • School of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan.
    • ,
  • Ying-Fang Su, DDS, MSD

      Affiliations

    • School of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan.
    • ,
  • Yu-Chao Chang, DDS, MS, PhD

      Affiliations

    • Institute of Stomatology, Chung Shan Medical University Hospital, Taichung, Taiwan.
    • Corresponding Author InformationAddress requests for reprint to Dr. Yu-Chao Chang, Institute of Stomatology, College of Oral Medicine, Chung Shan, Taichung, Taiwan.

References 

  1. Chang YC , Yang SF , Huang FM , Tai KW , Hsieh YS . Induction of tissue plasminogen activator gene expression by proinflammatory cytokines in human pulp and gingival fibroblasts . J Endod . 2003;29:118–120
  2. Chang YC , Yang SF , Huang FM , Liu CM , Tai KW , Hsieh YS . Proinflammatory cytokines induce cyclooxygenase-2 mRNA and protein expression in human pulp cell cultures . J Endod . 2003;29:201–204
  3. Chang YC , Huang FM , Yang SF , et al.   Induction of cyclooxygenase-2 mRNA and protein expression in human pulp cells stimulated with black-pigmented Bacteroides . J Endod . 2003;29:240–243
  4. Coil J , Tam E , Waterfield JD . Proinflammatory cytokine profiles in pulp fibroblasts stimulated with lipopolysaccaride and methyl mercaptan . J Endod . 2004;30:88–91
  5. Tuncer LI , Lee JI , Baek SH , Lim SS . Substance P expression is elevated in inflamed human periradicular tissue . J Endod . 2004;30:329–332
  6. Chu SC , Tsai CH , Yang SF , et al.   Induction of vascular endothelial growth factor gene expression by proinflammatory cytokines in human pulp and gingival fibroblasts . J Endod . 2004;30:704–707
  7. Sternlicht WD , Werb Z . How matrix metalloproteinases regulate cell behavior . Annu Rev Cell Dev Biol . 2001;17:463–516
  8. Werb Z . Proteinases and matrix degradation . In: Kelly WN , Harris FD , Ruddy S , Sledge CB editor. Textbook of rheumatology . 3rd ed.. Philadelphia: Saunders; 1989;p. 300–321
  9. Woessner JF . Matrix metalloproteinases and their inhibitors in connective tissue remodeling . FASEB . 1991;5:2145–2154
  10. Panagakos FS , O'Boskey JF , Rodriguez E . Regulation of pulp cell matrix metalloproteinases production by cytokines and lipopolysaccharides . J Endod . 1996;22:358–361
  11. O'Boskey JF , Panagakos FS . Cytokines stimulate matrix metalloproteinases production by human pulp cells during long-term culture . J Endod . 1998;24:7–10
  12. Chang YC , Yang SF , Hsieh YS . Regulation of matrix metalloproteinases-2 production by cytokines and pharmacological agents in human pulp cell cultures . J Endod . 2001;27:679–682
  13. Chang YC , Lai CC , Yang SF , Chan Y , Hsieh YS . Stimulation of matrix metalloproteinases by black-pigmented Bacteroides in human pulp and periodontal ligament cell cultures . J Endod . 2002;28:90–93
  14. Huang FM , Yang SF , Hsieh YS , Liu CM , Yang LC , Chang YC . Examination of the signal transduction pathways involved in matrix metalloproteinases-2 in human pulp cells . Oral Surg Oral Med Oral Pathol Oral Radiol Endod . 2004;97:398–403
  15. Shim SJ , Lee JI , Baek SH , Lim SS . Tissue levels of matrix metalloproteinases in pulps and periopical lesons . J Endod . 2002;28:313–315
  16. Gusman H , Santana RB , Zehnder M . Matrix metalloproteinases levels and gelatinolytic activity in clinically health and inflamed human dental pulps . Eur J Oral Sci . 2002;110:353–357
  17. Tsai CH , Huang FM , Yang LC , Chou MY , Chang YC . Immunohistochemical localization of cyclooxygenase-2 in radicular cysts . Int Endod J . 2002;35:854–858
  18. Tsai CH , Hsieh YS , Yang SF , Chou MY , Chang YC . Matrix metalloproteinase 2 and 9 expression in human oral squamous cell carcinoma and the effect of protein kinase C inhibitors: preliminary observations . Oral Surg Oral Med Oral Pathol Oral Radiol Endod . 2003;95:710–716
  19. Tsai CH , Weng SF , Yang LC , Huang FM , Chen YR , Chang YC . Immunohistochemical localization of tissue type plasminogen activator and type I plasminogen activator inhibitor in radicular cysts . J Oral Pathol Med . 2004;33:156–161
  20. Tani-Ishii N , Wang CY , Stashenko P . Immunolocalization of bone-resorptive cytokines in rat pulp and periapical lesions following surgical pulp exposure . Oral Microbiol Immunol . 1995;10:213–219

PII: S0099-2399(06)61108-4

doi: 10.1097/01.don.0000164851.55389.4e

Journal of Endodontics
Volume 31, Issue 12 , Pages 860-862 , December 2005

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