Journal of Endodontics
Volume 16, Issue 2 , Pages 78-84 , February 1990

Effects of injury and inflammation on pulpal and periapical nerves

  • Margaret R. Byers, PhD

      Affiliations

    • Corresponding Author InformationAddress requests for reprints to Dr. Byers, Department of Anesthesiology, RN-10, University of Washington, Seattle, WA 98195.
    • Dr. Byers is a research professor, Departments of Anesthesiology, Endodontics, and Biological Structure, University of Washington, Seattle, WA. Drs. Khayat, Kimberly, and Taylor are affiliated with the Department of Endodontics, University of Washington.
    • ,
  • Patrick E. Taylor, DDS, MSD

      Affiliations

    • Dr. Byers is a research professor, Departments of Anesthesiology, Endodontics, and Biological Structure, University of Washington, Seattle, WA. Drs. Khayat, Kimberly, and Taylor are affiliated with the Department of Endodontics, University of Washington.
    • ,
  • Bertrand G. Khayat, DDS, MSD

      Affiliations

    • Dr. Byers is a research professor, Departments of Anesthesiology, Endodontics, and Biological Structure, University of Washington, Seattle, WA. Drs. Khayat, Kimberly, and Taylor are affiliated with the Department of Endodontics, University of Washington.
    • ,
  • Charles L. Kimberly, DDS, MSD

      Affiliations

    • Dr. Byers is a research professor, Departments of Anesthesiology, Endodontics, and Biological Structure, University of Washington, Seattle, WA. Drs. Khayat, Kimberly, and Taylor are affiliated with the Department of Endodontics, University of Washington.

References 

  1. Gunji T. Morphological work on the sensitivity of dentin. Arch Histol Japn. 1982;45:45–60
  2. Byers MR. Dental sensory receptors. Int Rev Neurobiol. 1984;25:39–93
  3. Maeda T, Iwanaga T, Fujita T, Kobayanashi S. Immunohistochemical demonstration of nerves in the predentin and dentin of human third molars with the use of an antiserum against neurofilament protein (NFP). Cell Tissue Res. 1986;243:469–475
  4. Akai M, Wakisaka S. The distribution of peptidergic nerves. In: Inoki R, Kudo T, Olgart L, eds. Dynamic aspects of the dental pulp. London: Chapman and Hall Ltd. (in press).
  5. Edwall B, Gazelius B, Frazekas A, theodorsson-Norheim E, Lundberg JM. Neuropeptide Y (NPY) and sympathetic control of blood flow in oral mucosa and dental pulp in the cat. Acta Physiol Scand. 1985;125:253–264
  6. Gazelius B, Edwall B, Olgart L, Lundberg JM, Hökfelt T, Fisher JA. Vasodilatory effects and coexistence of calcitonin gene-related peptide (CGRP) and substance P in sensory neurons of cat dental pulp. Acta Physiol Scand. 1987;130:33–40
  7. Silverman JD, Kruger L. Calcitonin-gene-related-peptide immunoreactive innervation of the rat head with emphasis on specialized sensory structure. J Comp Neurol. 1989;280:303–330
  8. Brain SD, Williams TJ, Tippins JR, Morris HR, MacIntyre I. Calcitonin gene-related peptide is a potent vasodilator. Nature. 1985;313:54–56
  9. Payan DG, McGillis JP, Renold FK, Mitsuhashi M, Goetzl EJ. The role of brain peptides in neuroimmunomodulation. Ann NY Acad Sci. 1987;496:182–191
  10. Taylor PE, Byers MR, Redd PE. Sprouting of CGRP nerve fibers in response to dentin injury in rat molars. Brain Res. 1988;461:371–376
  11. Kimberly CL, Byers MR. Inflammation of rat molar pulp and periodontium causes increased calcitonin gene related peptide and axonal sprouting. Anat Rec. 1988;222:289–300
  12. Khayat BG, Byers MR, Taylor PE, Mecifi KB, Kimberly CL. Responses of nerve fibers to pulpal inflammation and periapical lesions in rat molars demonstrated by calcitonin gene-related peptide immunocytochemistry. J Endodon. 1988;14:577–587
  13. Taylor PE, Byers MR. Response of CGRP-immunoreactive nerve fibers to limited pulpitis and healing in rat molars. Arch Oral Biol (in press).
  14. Byers MR, Närhi MVO, Mecifi KB. Acute and chronic reactions of dental sensory nerve fibers to cavities and desiccation in rat molars. Anat Rec. 1988;221:872–883
  15. Lilja J, Nordenvall KJ, Brännström M. Dentin sensitivity, odontoblasts and nerves under desiccated or infected experimental cavities. Swed Dent J. 1982;6:93–103
  16. Olgart LM. The role of local factors in dentin and pulp intradental pain mechanisms. J Dent Res. 1985;64(special issue):572–578
  17. Trowbridge HO. Intradental sensory units: physiological and clinical aspects. J Endodon. 1985;11:489–498
  18. Brännström M. Dentin and pulp in restorative dentistry. London: Wolf Medical Publications; 1981;
  19. Karisson UL, Penney DA. Natural densensitization of exposed tooth roots in dogs. J Dent Res. 1975;54:982–986
  20. Hirvonen TJ, Närhi MVO, Hakumaki MDK. The excitability of dog pulp nerves in relation to the condition of dentin surface. J Endodon. 1984;10:294–298
  21. Plackova A. Pathologic changes in the innervation of the dental pulp during carious process. J Dent Res. 1966;45:62–65
  22. Pashley D. Dentin-predentin complex and its permeability: physiologic overview. J Dent Res. 1985;64(special issue):613–620
  23. Yamaura Y. Immunohistochemical investigations on the nerve fibers of the dental pulp after the cavity preparation. Jpn J Conserv Dent. 1987;30:824–838
  24. Brown RD. The failure of local anesthesia in acute inflammation. Br Dent J. 1981;151:47–51
  25. Iadarola MJ, Draisoi G. Elevation of spinal cord dynorphin mRNA compared to dorsal root ganglion peptide mRNAs during peripheral inflammation. In: Besson JM, Guilbaud G editor. The arthritic rat as a model of clinical pain?. New York: Elsevier; 1988;p. 173–183
  26. Levine JD, Coderre TJ, Basbaum AI. The peripheral nervous system and the inflammatory process. Pain Res Clin Managem. 1988;3:33–43
  27. Kvinnsland I, Kvinnsland S. Changes in CGRP-immunoreactive nerve fibers during experimental tooth movement in rats. Eur J Orthod (in press).
  28. Terenghi G, Zhang SQ, Unger WG, Polak J. Morphological changes of sensory CGRP-immunoreactive and sympathetic nerves in peripheral tissues following chronic denervation. Histochemistry. 1986;86:89–95
  29. Lindholm D, Heumann R, Meyer M, Thoenen H. Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve. nature. 1987;330:658–659
  30. Byers MR, Bothwell MA, Mecifi KB, Schatteman GC. Interactions of nerves and pulp cells in normal and injured teeth analysed by LM and EM immunocytochemistry for NGF-receptor. Neurosci Abstracts. 1988;14:1169

* This research was supported by NIH Grant DE 05159 to Dr. Byers and by NIH Grant 2-S07-RR05346 (BSRG) and the Graduate Endodontics Fund, University of Washington. Drs. C. L. Kimberly and P. E. Taylor received salary support from the U.S. Navy. Dr. B. G. Khayat received partial salary support from NIH Grant AG 00122.

PII: S0099-2399(06)81568-2

doi: 10.1016/S0099-2399(06)81568-2

Journal of Endodontics
Volume 16, Issue 2 , Pages 78-84 , February 1990

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