Journal of Endodontics
Volume 17, Issue 2 , Pages 76-79 , February 1991

Lack of correlation between the amount of eugenol released from zinc oxide-eugenol sealer and cytotoxicity of the sealer

  • Tomoharu Maseki, DDS

      Affiliations

    • Corresponding Author InformationAddress requests for reprints to Dr. Tomoharu Maseki, Department of Endodontics, School of Dentistry, Aichi-Gakuin University, 2–11 Suemoridori, Chikusa-ku, Nagoya 464 Japan.
    • Drs. Maseki, Nakata, Kohsaka, Kobayashi, Hirano, and Nakamura are members of the Department of Endodontics, School of Dentistry, Aichi-Gakuin University
    • ,
  • Kazuhiko Nakata, DDS

      Affiliations

    • Drs. Maseki, Nakata, Kohsaka, Kobayashi, Hirano, and Nakamura are members of the Department of Endodontics, School of Dentistry, Aichi-Gakuin University
    • ,
  • Toshiaki Kohsaka, DDS

      Affiliations

    • Drs. Maseki, Nakata, Kohsaka, Kobayashi, Hirano, and Nakamura are members of the Department of Endodontics, School of Dentistry, Aichi-Gakuin University
    • ,
  • Fuminori Kobayashi, DDS

      Affiliations

    • Drs. Maseki, Nakata, Kohsaka, Kobayashi, Hirano, and Nakamura are members of the Department of Endodontics, School of Dentistry, Aichi-Gakuin University
    • ,
  • Shinei Hirano, DDS

      Affiliations

    • Drs. Maseki, Nakata, Kohsaka, Kobayashi, Hirano, and Nakamura are members of the Department of Endodontics, School of Dentistry, Aichi-Gakuin University
    • ,
  • Hiroshi Nakamura, DDS, PhD

      Affiliations

    • Drs. Maseki, Nakata, Kohsaka, Kobayashi, Hirano, and Nakamura are members of the Department of Endodontics, School of Dentistry, Aichi-Gakuin University

References 

  1. Grossman LI. Endodontic practice. In: 10th ed. Philadelphia: Lea & Febiger; 1981;p. 277
  2. Weine FS. Endodontic therapy. In: 2nd ed.. St. Louis: CV Mosby; 1976;p. 258–260
  3. Roberts RB, Baker LB. Aeration after ethylene oxide sterilization. Anaesthesia. 1972;27:272–282
  4. Nakamura H, Sakakibara F, Matsumoto Y, Hirano S, Hayakawa H, Sakai K, et al. Study on the cytotoxicity of root canal filling materials. J Endodon. 1986;12:156–160
  5. Kawahara H, Yamagami A, Nakamura M. Biological testing of dental materials by means of tissue culture. Int Dent J. 1968;18:443–467
  6. Phillips HJ, Terryberry JE. Counting activity metabolizing tissue cultured cells. Exp Cell Res. 1957;13:341–347
  7. Phillips RW. Skinner's science of dental materials. In: 8th ed. Philadelphia: WB Saunders; 1982;p. 98–107
  8. Molnar EJ. Residual eugenol from zinc oxide-eugenol compounds. J Dent Res. 1967;46:645–649
  9. Meryon SD, Johnson SG, Smith AJ. Eugenol release and the cytotoxicity of different zinc oxide-eugenol combinations. J Dent. 1988;16:66–70
  10. Hensten-Pettersen A, Helgeland K. Evaluation of biologic effects of dental materials using four different cell culture techniques. Scand J Dent Res. 1977;85:291–296
  11. Erausquin H, Muruzabal M. Root canal fillings with zinc oxide-eugenol cement in the rat molar. Oral Surg. 1967;24:547–558
  12. Koch G, Magnusso NB, Nyquist G. Contact allergy to medicaments and materials used in dentistry. (II) Sensitivity to eugenol and colophony. Odontol Revy. 1973;22:275–289
  13. Tyas MJ. A method for the in vitro toxicity testing of dental restorative materials. J Dent Res. 1977;56:1285–1290
  14. Valle GF, Taintor JF, Marsh CL. The effect of varying liquid-to-powder ratio to zinc oxide and eugenol of rat pulpal respiration. J Endodon. 1980;6:400–404
  15. Lindqvist L, Otteskog P. Eugenol: liberation from dental materials and effect on human diploid fibroblast cells. Scand J Dent. 1981;89:552–556
  16. Hume WR. Effect of eugenol on respiration and division in human pulp, mouse fibroblasts, and liver cells in vitro. J Dent Res. 1984;63:1262–1265
  17. Barkin ME, Boyd JP, Cohen S. Acute allergic reaction to eugenol. Oral Surg. 1984;57:441–442
  18. Vishteh A, Thomas I, Imamura T. Eugenol modulation of the immune response in mice. Immunopharmacology. 1986;12:187–192
  19. Watts A, Paterson RC. Pulpal response to a zinc oxide-eugenol cement. Int Endod J. 1987;20:82–86
  20. Fujisawa S, Masuhara E. Binding of eugenol and O-ethoxybenzoic acid to bovine serum albumin. J Dent Res. 1981;60:860–864

PII: S0099-2399(06)81612-2

doi: 10.1016/S0099-2399(06)81612-2

Journal of Endodontics
Volume 17, Issue 2 , Pages 76-79 , February 1991

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