Journal of Endodontics
Volume 33, Issue 7 , Pages 773-781 , July 2007

Update on the Adaptive Immune Responses of the Dental Pulp

  • Chin-Lo Hahn, MS, PhD, DDS
    • ,
  • Frederick R. Liewehr, DDS, MS

      Affiliations

    • Corresponding Author InformationAddress requests for reprints to Dr, Frederick R. Liewehr, Department of Endodontics, School of Dentistry, Virginia Commonwealth University, 520 North 12th Street, Richmond, VA 23298-0566.

References 

  1. Sawa Y, Yoshida S, Shibata KI, Suzuki M, Mukaida A. Vascular endothelium of human dental pulp expresses diverse adhesion molecules for leukocyte emigration. Tissue Cell. 1998;30(2):281–291
  2. Nakanishi T, Takahashi K, Ozaki K, Nakae H, Matsuo T. An immunohistologic study on the localization of selected bacteria and chemokines in human deep-carious teeth. In:  Ishikawa T,  Takahashi K,  Maeda T,  Suda H,  Shimono M,  Inoue T editor. Proceedings of the International Conference on Dentin/Pulp Complex 2001, Chiba, Japan. Chicago: Quintessence; 2001;p. 143–145
  3. Nakanishi T, Takahashi K, Hosokawa Y, Adachi T, Nakae H, Matsuo T. Expression of macrophage inflammatory protein 3alpha in human inflamed dental pulp tissue. J Endod. 2005;31(2):84–87
  4. Sozzani S, Locati M, Zhou D, et al. Receptors, signal transduction, and spectrum of action of monocyte chemotactic protein-1 and related chemokines. J Leukoc Biol. 1995;57(5):788–794
  5. Liao F, Rabin RL, Smith CS, Sharma G, Nutman TB, Farber JM. CC-chemokine receptor 6 is expressed on diverse memory subsets of T cells and determines responsiveness to macrophage inflammatory protein 3 alpha. J Immunol. 1999;162(1):186–194
  6. Bonecchi R, Bianchi G, Bordignon PP, et al. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J Exp Med. 1998;187(1):129–134
  7. Lebre MC, Burwell T, Vieira PL, et al. Differential expression of inflammatory chemokines by Th1- and Th2-cell promoting dendritic cells: a role for different mature dendritic cell populations in attracting appropriate effector cells to peripheral sites of inflammation. Immunol Cell Biol. 2005;83(5):525–535
  8. Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, Locati M. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 2004;25(12):677–686
  9. Nagaoka S, Tokuda M, Sakuta T, et al. Interleukin-8 gene expression by human dental pulp fibroblast in cultures stimulated with Prevotella intermedia lipopolysaccharide. J Endod. 1996;22(1):9–12
  10. Yang LC, Huang FM, Lin CS, Liu CM, Lai CC, Chang YC. Induction of interleukin-8 gene expression by black-pigmented Bacteroides in human pulp fibroblasts and osteoblasts. Int Endod J. 2003;36(11):774–779
  11. Park SH, Hsiao GY, Huang GT. Role of substance P and calcitonin gene-related peptide in the regulation of interleukin-8 and monocyte chemotactic protein-1 expression in human dental pulp. Int Endod J. 2004;37(3):185–192
  12. Chang J, Zhang C, Tani-Ishii N, Shi S, Wang CY. NF-kappaB activation in human dental pulp stem cells by TNF and LPS. J Dent Res. 2005;84(11):994–998
  13. Huang GT, Potente AP, Kim JW, Chugal N, Zhang X. Increased interleukin-8 expression in inflamed human dental pulps. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;88(2):214–220
  14. Kitayama J, Carr MW, Roth SJ, Buccola J, Springer TA. Contrasting responses to multiple chemotactic stimuli in transendothelial migration: heterologous desensitization in neutrophils and augmentation of migration in eosinophils. J Immunol. 1997;158(5):2340–2349
  15. Luu NT, Rainger GE, Nash GB. Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils. J Immunol. 2000;164(11):5961–5969
  16. Jiang Y, Russell TR, Schilder H, Graves DT. Endodontic pathogens stimulate monocyte chemoattractant protein-1 and interleukin-8 in mononuclear cells. J Endod. 1998;24(2):86–90
  17. Ko HJ, Lim SS. Production of macrophage inflammatory protein (MIP)-1alpha and MIP-1beta by human polymorphonuclear neutrophils stimulated with Porphyromonas endodontalis lipopolysaccharide. J Endod. 2002;28(11):754–757
  18. Yoshie O, Imai T, Nomiyama H. Chemokines in immunity. Adv Immunol. 2001;78:57–110
  19. Durand SH, Flacher V, Romeas A, et al. Lipoteichoic acid increases TLR and functional chemokine expression while reducing dentin formation in in vitro differentiated human odontoblasts. J Immunol. 2006;176(5):2880–2887
  20. Galkina E, Thatte J, Dabak V, Williams MB, Ley K, Braciale TJ. Preferential migration of effector CD8+ T cells into the interstitium of the normal lung. J Clin Invest. 2005;115:3473–3483
  21. Thomsen AR, Nansen A, Madsen AN, Bartholdy C, Christensen JP. Regulation of T cell migration during viral infection: role of adhesion molecules and chemokines. Immunol Lett. 2003;85(2):119–127
  22. Kunkel EJ, Butcher EC. Plasma-cell homing. Nat Rev Immunol. 2003;3(10):822–829
  23. Mellman I, Steinman RM. Dendritic cells: specialized and regulated antigen processing machines. Cell. 2001;106(3):255–258
  24. Trombetta ES, Mellman I. Cell biology of antigen processing in vitro and in vivo. Annu Rev Immunol. 2005;23:975–1028
  25. Mellman I, Turley SJ, Steinman RM. Antigen processing for amateurs and professionals. Trends Cell Biol. 1998;8(6):231–237
  26. Lanzavecchia A. Receptor-mediated antigen uptake and its effect on antigen presentation to class II—restricted T lymphocytes. Annu Rev Immunol. 1990;8(1):773–793
  27. Sakurai K, Okiji T, Suda H. Co-increase of nerve fibers and HLA-DR- and/or factor-XIIIa-expressing dendritic cells in dentinal caries-affected regions of the human dental pulp: an immunohistochemical study. J Dent Res. 1999;78(10):1596–1608
  28. Izumi T, Kobayashi I, Okamura K, et al. An immunohistochemical study of HLA-DR and alpha 1-antichymotrypsin- positive cells in the pulp of human non-carious and carious teeth. Arch Oral Biol. 1996;41(7):627–630
  29. Okiji T, Suda H, Kawashima N, Kaneko T, Sakurai K. Response of pulpal dendritic cells to microbial challenges across dentin. In:  Ishikawa T,  Takahashi K,  Maeda T,  Suda H,  Shimono M,  Inoue T editor. Proceedings of the International Conference on Dentin/Pulp Complex 2001, Chiba, Japan. Chicago: Quintessence; 2001;p. 24–30
  30. Fujiwara N, Kobayashi K. Macrophages in inflammation. Curr Drug Targets Inflamm Allergy. 2005;4(3):281–286
  31. D’Souza R, Brown L, Newland J, Levy B, Lachman L. Detection and characterization of interleukin-1 in human dental pulps. Archs Oral Biol. 1989;34(5):307–313
  32. Pezelj-Ribaric S, Anic I, Brekalo I, Miletic I, Hasan M, Simunovic-Soskic M. Detection of tumor necrosis factor alpha in normal and inflamed human dental pulps. Arch Med Res. 2002;33(5):482–484
  33. Gordon S, Taylor PR. Monocyte and macrophage heterogeneity. Nat Rev Immunol. 2005;5(12):953–964
  34. Janeway CA, Travers P, Walport M, Capra JD. Immunobiology (The immune system in health and disease). 4th ed.. New York: Gerland; 1999;
  35. de Saint-Vis B, Vincent J, Vandenabeele S, et al. A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment. Immunity. 1998;9(3):325–336
  36. Bell D, Chomarat P, Broyles D, et al. In breast carcinoma tissue, immature dendritic cells reside within the tumor, whereas mature dendritic cells are located in peritumoral areas. J Exp Med. 1999;190(10):1417–1426
  37. Levin LG, Rudd A, Bletsa A, Reisner H. Expression of IL-8 by cells of the odontoblast layer in vitro. Eur J Oral Sci. 1999;107(2):131–137
  38. Farges JC, Romeas A, Melin M, et al. TGF-beta1 induces accumulation of dendritic cells in the odontoblast layer. J Dent Res. 2003;82(8):652–656
  39. Randolph GJ, Inaba K, Robbiani DF, Steinman RM, Muller WA. Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo. Immunity. 1999;11(6):753–761
  40. Zhang J, Kawashima N, Suda H, Nakano Y, Takano Y, Azuma M. The existence of CD11c+ sentinel and F4/80+ interstitial dendritic cells in dental pulp and their dynamics and functional properties. Int Immunol. 2006;18:1375–1384Epub 2006 July 18.
  41. Hahn CL, Schenkein HA, Tew JG. Endocarditis-associated oral streptococci promote rapid differentiation of monocytes into mature dendritic cells. Infect Immun. 2005;73(8):5015–5021
  42. Delneste Y, Herbault N, Galea B, Magistrelli G, Bazin I, Bonnefoy JY, et al. Vasoactive intestinal peptide synergizes with TNF-alpha in inducing human dendritic cell maturation. J Immunol. 1999;163(6):3071–3075
  43. Lee AW, Truong T, Bickham K, Fonteneau JF, Larsson M, Da Silva I, et al. A clinical grade cocktail of cytokines and PGE2 results in uniform maturation of human monocyte-derived dendritic cells: implications for immunotherapy. Vaccine. 2002;20(Suppl 4):A8–A22
  44. Dunzendorfer S, Kaser A, Meierhofer C, Tilg H, Wiedermann CJ. Cutting edge: peripheral neuropeptides attract immature and arrest mature blood-derived dendritic cells. J Immunol. 2001;166(4):2167–2172
  45. Katou F, Ohtani H, Nakayama T, Nagura H, Yoshie O, Motegi K. Differential expression of CCL19 by DC-Lamp+ mature dendritic cells in human lymph node versus chronically inflamed skin. J Pathol. 2003;199(1):98–106
  46. Jotwani R, Cutler CW. Multiple dendritic cell (DC) subpopulations in human gingiva and association of mature DCs with CD4+ T-cells in situ. J Dent Res. 2003;82(9):736–741
  47. Jontell M, Eklof C, Dahlgren UI, Bergenholtz G. Difference in capacity between macrophages and dendritic cells from rat incisor pulp to provide accessory signals to concanavalin-A-stimulated T-lymphocytes. J Dent Res. 1994;73(5):1056–1060
  48. Yoshida H, Jontell M, Sundqvist G, Bergenholtz G. Effect of sonicated material from Fusobacterium nucleatum on the functional capacity of accessory cells derived from dental pulp. Oral Microbiol Immunol. 1995;10(4):208–212
  49. Lutz MB, Schuler G. Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity?. Trends in Immunology. 2002;23(9):445–449
  50. Steinman RM, Hawiger D, Nussenzweig MC. Tolerogenic dendritic cells. Annu Rev Immunol. 2003;21:685–711
  51. Jonuleit H, Schmitt E, Schuler G, Knop J, Enk AH. Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J Exp Med. 2000;192(9):1213–1222
  52. Geissmann F, Revy P, Regnault A, Lepelletier Y, Dy M, Brousse N, et al. TGF-beta 1 prevents the noncognate maturation of human dendritic Langerhans cells. J Immunol. 1999;162(8):4567–4575
  53. Laxmanan S, Robertson SW, Wang E, Lau JS, Briscoe DM, Mukhopadhyay D. Vascular endothelial growth factor impairs the functional ability of dendritic cells through Id pathways. Biochem Biophys Res Commun. 2005;334(1):193–198
  54. Oyama T, Ran S, Ishida T, et al. Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-kappa B activation in hemopoietic progenitor cells. J Immunol. 1998;160(3):1224–1232
  55. Steinbrink K, Wolfl M, Jonuleit H, Knop J, Enk AH. Induction of tolerance by IL-10-treated dendritic cells. J Immunol. 1997;159(10):4772–4780
  56. Wallet MA, Sen P, Tisch R. Immunoregulation of dendritic cells. Clin Med Res. 2005;3(3):166–175
  57. Artese L, Rubini C, Ferrero G, Fioroni M, Santinelli A, Piattelli A. Vascular endothelial growth factor (VEGF) expression in healthy and inflamed human dental pulps. J Endod. 2002;28(1):20–23
  58. Hahn CL, Best AM, Tew JG. Cytokine induction by Streptococcus mutans and pulpal pathogenesis. Infect Immun. 2000;68(12):6785–6789
  59. Piattelli A, Rubini C, Fioroni M, Tripodi D, Strocchi R. Transforming growth factor-beta 1 (TGF-beta 1) expression in normal healthy pulps and in those with irreversible pulpitis. Int Endod J. 2004;37(2):114–119
  60. Mason D, Powrie F. Control of immune pathology by regulatory T cells. Curr Opin Immunol. 1998;10(6):649–655
  61. Hosken NA, Shibuya K, Heath AW, Murphy KM, O’Garra A. The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model. J Exp Med. 1995;182(5):1579–1584
  62. Hahn CL, Best AM, Tew JG. Comparison of type 1 and type 2 cytokine production by mononuclear cells cultured with streptococcus mutans and selected other caries bacteria. J Endod. 2004;30(5):333–338
  63. Lucey DR, Clerici M, Shearer GM. Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases. Clin Microbiol Rev. 1996;9(4):532–562
  64. Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol. 1989;7:145–173
  65. O’Garra A. Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity. 1998;8(3):275–283
  66. van Oosterhout AJ, Bloksma N. Regulatory T-lymphocytes in asthma. Eur Respir J. 2005;26(5):918–932
  67. Maizels RM. Infections and allergy—helminths, hygiene and host immune regulation. Curr Opin Immunol. 2005;17(6):656–661
  68. Hansen G, Berry G, DeKruyff RH, Umetsu DT. Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. J Clin Invest. 1999;103(2):175–183
  69. McGuirk P, Mills KH. Pathogen-specific regulatory T cells provoke a shift in the Th1/Th2 paradigm in immunity to infectious diseases. Trends Immunol. 2002;23(9):450–455
  70. Beissert S, Schwarz A, Schwarz T. Regulatory T cells. J Invest Dermatol. 2006;126(1):15–24
  71. Cottrez F, Hurst SD, Coffman RL, Groux H. T regulatory cells 1 inhibit a Th2-specific response in vivo. J Immunol. 2000;165(9):4848–4853
  72. McGuirk P, McCann C, Mills KH. Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis. J Exp Med. 2002;195(2):221–231
  73. Gershon RK, Cohen P, Hencin R, Liebhaber SA. Suppressor T cells. J Immunol. 1972;108(3):586–590
  74. Damoiseaux J. Regulatory T cells: back to the future. Neth J Med. 2006;64(1):4–9
  75. Fiorentino DF, Zlotnik A, Vieira P, et al. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. J Immunol. 1991;146(10):3444–3451
  76. Buelens C, Verhasselt V, De Groote D, Thielemans K, Goldman M, Willems F. Interleukin-10 prevents the generation of dendritic cells from human peripheral blood mononuclear cells cultured with interleukin-4 and granulocyte/macrophage-colony-stimulating factor. Eur J Immunol. 1997;27(3):756–762
  77. Rauschenberger CR, Bailey JC, Cootauco CJ. Detection of human IL-2 in normal and inflamed dental pulps. J Endod. 1997;23(6):366–370
  78. Anderson LM, Dumsha TC, McDonald NJ, Spitznagel JK. Evaluating IL-2 levels in human pulp tissue. J Endod. 2002;28(9):651–655
  79. Plitnick LM, Jordan RA, Banas JA, et al. Lipoteichoic acid inhibits interleukin-2 (IL-2) function by direct binding to IL-2. Clin Diagn Lab Immunol. 2001;8(5):972–979
  80. Noble A, Giorgini A, Leggat JA. Cytokine-induced IL-10-secreting CD8 T cells represent a phenotypically distinct suppressor T cell lineage. Blood. 2006;107:4475–4483Epub 2006 Feb 7.
  81. Mosmann TR, Li L, Sad S. Functions of CD8 T-cell subsets secreting different cytokine patterns. Semin Immunol. 1997;9(2):87–92
  82. Izumi T, Kobayashi I, Okamura K, Sakai H. Immunohistochemical study on the immunocompetent cells of the pulp in human non-carious and carious teeth. Archs. Oral Biol. 1995;40:609–614
  83. Hahn CL, Falkler WA, Siegel MA. A study of T and B cells in pulpal pathosis. J Endod. 1989;15(1):20–26
  84. Hensbergen PJ, Wijnands PG, Schreurs MW, Scheper RJ, Willemze R, Tensen CP. The CXCR3 targeting chemokine CXCL11 has potent antitumor activity in vivo involving attraction of CD8+ T lymphocytes but not inhibition of angiogenesis. J Immunother. 2005;28(4):343–351
  85. Cole KE, Strick CA, Paradis TJ, et al. Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. J Exp Med. 1998;187(12):2009–2021
  86. Monsurro V, Nagorsen D, Wang E, et al. Functional heterogeneity of vaccine-induced CD8(+) T cells. J Immunol. 2002;168(11):5933–5942
  87. Rennick D, Davidson N, Berg D. Interleukin-10 gene knock-out mice: a model of chronic inflammation. Clin Immunol Immunopathol. 1995;76(3 Pt 2):S174–S178
  88. Levings MK, Sangregorio R, Galbiati F, Squadrone S, de Waal Malefyt R, Roncarolo MG. IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells. J Immunol. 2001;166(9):5530–5539
  89. Zehnder M, Delaleu N, Du Y, Bickel M. Cytokine gene expression–part of host defence in pulpitis. Cytokine. 2003;22(3–4):84–88
  90. Spellberg B, Edwards JE. Type 1/Type 2 immunity in infectious diseases. Clin Infect Dis. 2001;32(1):76–102
  91. Lu HX, Xiao MZ, Niu ZY, et al. Effect of IL-1ra on human dental pulp cells and pulpal inflammation. Int Endod J. 2002;35(10):807–811
  92. Taylor PE, Byers MR. An immunocytochemical study of the morphological reaction of nerves containing calcitonin gene-related peptide to microabscess formation and healing in rat molars. Arch Oral Biol. 1990;35(8):629–638
  93. Byers MR, Taylor PE, Khayat BG, Kimberly CL. Effects of injury and inflammation on pulpal and periapical nerves. J Endod. 1990;16(2):78–84
  94. Bayry J, Lacroix-Desmazes S, Kazatchkine MD, Hermine O, Tough DF, Kaveri SV. Modulation of dendritic cell maturation and function by B lymphocytes. J Immunol. 2005;175(1):15–20
  95. Lund FE, Garvy BA, Randall TD, Harris DP. Regulatory roles for cytokine-producing B cells in infection and autoimmune disease. Curr Dir Autoimmun. 2005;8:25–54
  96. Speer ML, Madonia JV, Heuer MA. Quantitative evaluation of the immunocompetence of the dental pulp. J Endod. 1977;3(11):418–423
  97. Maddison SE, Stewart CC, Farshy CE, Reimer CB. The relationship of race, sex, and age to concentrations of serum immunoglobulins expressed in international units in healthy adults in the USA. Bull World Health Organ. 1975;52(2):179–185
  98. French MA, Harrison G. Serum IgG subclass concentrations in healthy adults: a study using monoclonal antisera. Clin Exp Immunol. 1984;56(2):473–475
  99. Shackelford PG, Granoff DM, Nahm MH, et al. Relation of age, race, and allotype to immunoglobulin subclass concentrations. Pediatr Res. 1985;19(8):846–849
  100. Pulver WH, Taubman MA, Smith DJ. Immune components in normal and inflamed human dental pulp. Arch Oral Biol. 1977;22(2):103–111
  101. Devey ME, Voak D. A critical study of the IgG subclasses of Rh anti-D antibodies formed in pregnancy and in immunized volunteers. Immunology. 1974;27(6):1073–1079
  102. Falkler WA, Martin SA, Tolba M, Siegel MA, Mackler BF. Reaction of pulpal immunoglobulins to oral microorganisms by an enzyme-linked immunosorbent assay. J Endod. 1987;13(6):260–266
  103. Hahn CL, Falkler WA. Antibodies in normal and diseased pulps reactive with microorganisms isolated from deep caries. J Endodon. 1992;18:28–31
  104. Stashenko P. Regulatory effect of monocytes on T cell proliferative responses to oral microbial antigens. Infect Immun. 1982;38(3):938–947
  105. Baker J, Tondreau S. The stimulation of human peripheral blood lymphocytes by oral bacteria: macrophage and T-cell dependence. J Dent Res. 1985;64(6):906–912
  106. Donaldson SL, Bick PH, Moore WE, Ranney RR, Burmeister JA, Tew JG. Polyclonal B-cell activating capacities of gram-positive bacteria frequently isolated from periodontally diseased sites. J Periodontal Res. 1982;17(6):569–575
  107. Carpenter AB, Sully EC, Ranney RR, Bick PH. T-cell regulation of polyclonal B-cell activation induced by extracts of oral bacteria associated with periodontal diseases. Infect Immun. 1984;43(1):326–336
  108. Bick PH, Carpenter AB, Holdeman LV, et al. Polyclonal B-cell activation induced by extracts of Gram-negative bacteria isolated from periodontally diseased sites. Infect Immun. 1981;34(1):43–49
  109. Gemmell E, Seymour GJ. Modulation of immune responses to periodontal bacteria. Curr Opin Periodontol. 1994;28–38
  110. Gemmell E, Seymour GJ. Cytokine profiles of cells extracted from humans with periodontal diseases. J Dent Res. 1998;77(1):16–26
  111. Seymour GJ, Gemmell E, Reinhardt RA, Eastcott J, Taubman MA. Immunopathogenesis of chronic inflammatory periodontal disease: cellular and molecular mechanisms. J Periodontal Res. 1993;28(6 Pt 2):478–486
  112. Farnoush A. Mast cells in human dental pulp. J Endod. 1987;13(7):362–363
  113. Miller GS, Sternberg RN, Piliero SJ, Rosenberg PA. Histologic identification of mast cells in human dental pulp. Oral Surg Oral Med Oral Pathol. 1978;46(4):559–566
  114. Zachrisson BU. Mast cells in human dental pulp. Arch Oral Biol. 1971;16(5):555–556
  115. Walsh LJ. Mast cells and oral inflammation. Crit Rev Oral Biol Med. 2003;14(3):188–198
  116. Dray A. Inflammatory mediators of pain. Br J Anaesth. 1995;75(2):125–131
  117. Holzer P. Peptidergic sensory neurons in the control of vascular functions: mechanisms and significance in the cutaneous and splanchnic vascular beds. Rev Physiol Biochem Pharmacol. 1992;121:49–146
  118. Bergenholtz G, Warfvinge J. Migration of leukocytes in dental pulp in response to plaque bacteria. Scand J Dent Res. 1982;90(5):354–362
  119. Bergenholtz G. Effect of bacterial products on inflammatory reactions in the dental pulp. Scand J Dent Res. 1977;85(2):122–129
  120. Bergenholtz G, Lindhe J. Effect of soluble plaque factors on inflammatory reactions in the dental pulp. Scand J Dent Res. 1975;83(3):153–158
  121. Adamkiewicz VW, Pekovic DD. Experimental pulpal Arthus allergy. Oral Surg Oral Med Oral Pathol. 1980;50(5):450–456
  122. Bergenholtz G, Ahlstedt S, Lindhe J. Experimental pulpitis in immunized monkeys. Scand J Dent Res. 1977;85(6):396–406
  123. Warfvinge J. Dental pulp inflammation; experimental studies in human and monkey teeth. Swed Dent J Suppl. 1986;39:1–36
  124. Sylvestre DL, Ravetch JV. A dominant role for mast cell Fc receptors in the Arthus reaction. Immunity. 1996;5(4):387–390
  125. Sylvestre DL, Ravetch JV. Fc receptors initiate the Arthus reaction: redefining the inflammatory cascade. Science. 1994;265(5175):1095–1098
  126. Sylvestre D, Clynes R, Ma M, Warren H, Carroll MC, Ravetch JV. Immunoglobulin G-mediated inflammatory responses develop normally in complement-deficient mice. J Exp Med. 1996;184(6):2385–2392
  127. Hazenbos WL, Gessner JE, Hofhuis FM, et al. Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice. Immunity. 1996;5(2):181–188
  128. Hargreaves K. Pain mechanisms of pulpodentin complex. In:  Hargreaves KM,  Goodis HE editor. Seltzer and Bender’s dental pulp. Chicago: Quintessence; 2002;p. 181–203
  129. Langeland K. Tissue response to dental caries. Endod Dent Traumatol. 1987;3(4):149–171
  130. Lundy T, Stanley HR. Correlation of pulpal histopathology and clinical symptoms in human teeth subjected to experimental irritation. Oral Surg. 1969;27(2):187–201
  131. Seltzer S, Bender IB. The dynamics of pulp inflammation: correlations between diagnostic data and actual histologic findings in the pulp. Oral Surg. 1963;16(7):846–871
  132. Narhi M, Yamamoto H, Ngassapa D, Hirvonen T. The neurophysiological basis and the role of inflammatory reactions in dentine hypersensitivity. Arch Oral Biol. 1994;39(Suppl):23S–30S
  133. Olgart L. Neural control of pulpal blood flow. Crit Rev Oral Biol Med. 1996;7(2):159–171
  134. Olgart L, Kerezoudis NP. Nerve-pulp interactions. Arch Oral Biol. 1994;39(Suppl):47S–54S
  135. Mudie AS, Holland GR. Local opioids in the inflamed dental pulp. J Endod. 2006;32(4):319–323
  136. Kudo T, Chang HL, Kuroi M, Wakisaka S, Akai M, Inoki R. Influences of bradykinin and substance P on the met-enkephalin-like peptide content in the rat incisor pulp. Neuropeptides. 1986;7(4):399–405
  137. Lepinski AM, Hargreaves KM, Goodis HE, Bowles WR. Bradykinin levels in dental pulp by microdialysis. J Endod. 2000;26(12):744–747
  138. Heyeraas KJ, Berggreen E. Interstitial fluid pressure in normal and inflamed pulp. Crit Rev Oral Biol Med. 1999;10(3):328–336
  139. Gilbert TM, Pashley DH, Anderson RW. Response of pulpal blood flow to intra-arterial infusion of endothelin. J Endod. 1992;18(5):228–231
  140. Luthman J, Luthman D, Hokfelt T. Occurrence and distribution of different neurochemical markers in the human dental pulp. Arch Oral Biol. 1992;37(3):193–208
  141. Romerio SC, Linder L, Haefeli WE. Neurokinin-1 receptor antagonist R116301 inhibits substance P-induced venodilation. Clin Pharmacol Ther. 1999;66(5):522–527

PII: S0099-2399(07)00002-7

doi: 10.1016/j.joen.2007.01.002

Journal of Endodontics
Volume 33, Issue 7 , Pages 773-781 , July 2007

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