Journal of Endodontics
Volume 34, Issue 1 , Pages 22-25, January 2008

Correlation between the Expression of c-Fos and Osteoclasts in Induced Periapical Lesions in Rats

  • Jing Yang, DDS
    • ,
  • Bin Peng, DDS, PhD

      Affiliations

    • Corresponding Author InformationAddress requests for reprints to Dr Bin Peng, Key Laboratory of Oral Biomedical Engineering of Ministry of Education, School and Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan City, P. R. China 430079.

Department of Operative Dentistry and Endodontics, School and Hospital of Stomatology, Wuhan University, Wuhan City, China.

published online 23 November 2007.

Abstract 

The experiment was undertaken to observe the correlation between the expression of c-Fos and osteoclasts in experimental periapical lesions in rats. Apical periodontitis was induced in Wistar rats by occlusal exposure of the pulp of their mandibular first molars. After the exposure, 25 Wistar rats were killed on days 0, 7, 14, 21, and 28. The jaws that contained the first molar were obtained and routinely prepared for immunohistochemistry and enzyme histochemistry. A few c-Fos–positive cells and osteoclasts could be observed on day 7, and both climaxed on day 14. In the 21-day and 28-day samples, the expression of c-Fos decreased, and fewer osteoclasts could be observed. From day 7 to day 28, a significant positive correlation was found between the expression of c-Fos and osteoclasts. These findings demonstrated that c-Fos might be associated with the differentiation of osteoclasts in the periapical lesions.

Key Words: c-Fos, experimental periapical lesions, osteoclast

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 20.00 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0099-2399(07)00709-1

doi:10.1016/j.joen.2007.07.034

Journal of Endodontics
Volume 34, Issue 1 , Pages 22-25, January 2008

Article Tools

* Image Usage & Resolution