Journal of Endodontics
Volume 33, Issue 11 , Pages 1329-1333 , November 2007

Effects of Root Canal Sealers on Lipopolysaccharide-induced Expression of Cyclooxygenase-2 mRNA in Murine Macrophage Cells

  • Dong Hee Lee, PhD

      Affiliations

    • Department of Dental Biomaterials Science and Dental Research Institute, School of Dentistry, Seoul National University, Seoul
  • ,
  • Na Ryoung Kim, BS

      Affiliations

    • Department of Dental Biomaterials Science and Dental Research Institute, School of Dentistry, Seoul National University, Seoul
  • ,
  • Bum-Soon Lim, PhD

      Affiliations

    • Department of Dental Biomaterials Science and Dental Research Institute, School of Dentistry, Seoul National University, Seoul
  • ,
  • Yong-Keun Lee, DDS, PhD

      Affiliations

    • Department of Dental Biomaterials Science and Dental Research Institute, School of Dentistry, Seoul National University, Seoul
  • ,
  • Kyu-Kye Hwang, PhD

      Affiliations

    • Department of Veterinary Medicine, Cheju National University, Jeju, Korea.
  • ,
  • Hyeong-Cheol Yang, PhD

      Affiliations

    • Department of Dental Biomaterials Science and Dental Research Institute, School of Dentistry, Seoul National University, Seoul
    • Corresponding Author InformationAddress requests for reprints to Hyeong-Cheol Yang, PhD, Department of Dental Biomaterials Science, School of Dentistry, Seoul National University, 28 Yeonkun-dong, Chongro-ku, Seoul 110-749, Korea.

References 

  1. Chávez de Paz LE, Dahlén G, Molander A, Möller A, Bergenholts G. Bacteria recovered from teeth with apical periodontitis after antimicrobial endodontic treatment. Int Endod J. 2003;36:500–508
  2. Gomes BPFA, Pinheiro ET, Gadê-Neto CR, et al. Microbiological examination of infected dental root canals. Oral Microbiol Immunol. 2004;19:71–76
  3. Lai CC, Huang FM, Yang HW, et al. Antimicrobial activity of four root canal sealers against endodontic pathogens. Clin Oral Invest. 2001;5:236–239
  4. Kayaoglu G, Erten H, Alaçam T, Ørstavik D. Short-term antibacterial activity of root canal sealers towards Enterococcus faecalis. Int Endod J. 2005;38:483–488
  5. Tai KW, Huang FM, Hunag MS, Chang YC. Assessment of the genotoxicity of resin and zinc-oxide eugenol-based root canal sealers using an in vitro mammalian test system. J Biomed Mater Res. 2002;59:73–77
  6. De Oliveira Mendes ST, Sobrinho APR, De Carvalho AT, De Souza Cortes MI, Vieira LQ. In vitro evaluation of the cytotoxicity of two root canal sealers on macrophage activity. J Endod. 2003;29:95–99
  7. Huang TH, Ding SJ, Hsu TZ, Lee ZD, Kao CT. Root canal sealers induce cytotoxicity and necrosis. J Mater Sci Mater Med. 2004;15:767–771
  8. Tagger M, Tagger E. Periapical reactions to calcium hydroxide-containing sealers and AH 26 in monkeys. Endod Dent Traumatol. 1989;5:139–146
  9. Tepel J, Darwisch M, Hoppe W. Reaction of inflamed periapical tissue to intracanal medicaments and root canal sealers. Endod Dent Traumatol. 1994;10:233–238
  10. Huang FM, Chou MY, Chang YC. Dentin bonding agents induce c-fos and c-jun protooncogenes expression in human gingival fibroblasts. Biomaterials. 2003;24:157–163
  11. Coon D, Gulati A, Cowan C, He J. The role of cyclooxygenase-2 (COX-2) in inflammatory bone resorption. J Endod. 2007;33:432–436
  12. Guven G, Altun C, Gunhan O, et al. Co-expression of cyclooxygenase-2 and vascular endothelial growth factor in inflamed human pulp: an immunohistochemical study. J Endod. 2007;33:18–20
  13. Holt CI, Hutchins MO, Pileggi R. A real time quantitative PCR analysis and correlation of COX-1 and COX-2 enzymes in inflamed dental pulps following administration of three different NSAIDs. J Endod. 2005;31:799–804
  14. Berenbaum F, Jacques C, Thomas G, Corvol MT, Béréziat G, Masliah J. Synergistic effect of interleukin-1 beta and tumor necrosis factor alpha on PGE2 production by articular chondrocytes does not involve PLA2 stimulation. Exp Cell Res. 1996;222:379–384
  15. Itho A, Nishihira J, Makita H, Miyamoto K, Yamaguchi E, Nishimura M. Effects of IL-1beta, TNF-alpha, and macrophage migration inhibitory factor on prostacyclin synthesis in rat pulmonary artery smooth muscle cells. Respirology. 2003;8:467–472
  16. Arias-Negrete S, Keller K, Chadee K. Proinflammatory cytokines regulate cyclooxygenase-2 mRNA expression in human macrophages. Biochem Biophys Res Commun. 1995;208:582–589
  17. Lee DH, Park JC, Suh H. Synergistic induction of cyclooxygenase-II by bacterial lipopolysaccharide in combination with particles of medical device materials in a murine macrophage cell line J774A.1. J Biomed Mater Res. 2001;55:547–553
  18. Torabinejad M, Ung B, Kettering JD. In vitro bacterial penetration of coronally unsealed endodontically treated teeth. J Endod. 1990;16:566–569
  19. Jiang J, Li H, Fahid FS, et al. Quantitative analysis of osteoclast-specific gene markers stimulated by lipopolysaccharide. J Endod. 2006;32:742–746
  20. Barrios-Rodiles M, Tiraloche G, Chadee K. Lipopolysaccharide modulates cyclooxygenase-2 transcriptionally and posttranscriptionally in human macrophages independently from endogenous IL-1 beta and TNF-alpha. J Immunol. 1999;163:963–969
  21. Wadleigh DJ, Reddy ST, Kopp E, Ghosh S, Herschman HR. Transcriptional activation of the cyclooxygenase-2 gene in endotoxin-treated RAW 264.7 macrophages. J Biol Chem. 2000;275:6259–6266
  22. Dean JL, Brook M, Clark AR, Saklatvala J. p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes. J Biol Chem. 1999;274:264–269
  23. Frevel MA, Bakheet T, Silva AM, Hissong TG, Khabar KS, Williams BR. p38 Mitogen-activated protein kinase-dependent and -independent signaling of mRNA stability of AU-rich element-containing transcripts. Mol Cell Biol. 2003;23:425–436
  24. Guhaniyogi J, Brewer G. Regulation of mRNA stability in mammalian cells. Gene. 2001;265:11–23
  25. Grzybowska EA, Wilczynska A, Siedlecki JA. Regulatory functions of 3’UTRs. Biochem Biophys Res Commun. 2001;288:291–295
  26. Bakheet T, Frevel M, Williams BR, Greer W, Khabar KS. ARED: human AU-rich element-containing mRNA database reveals an unexpectedly diverse functional repertoire of encoded proteins. Nucleic Acids Res. 2001;29:246–254
  27. Tebo J, Der S, Frevel M, Khabar KS, Williams BR, Hamilton TA. Heterogeneity in control of mRNA stability by AU-rich elements. J Biol Chem. 2003;278:12085–12093

PII: S0099-2399(07)00743-1

doi: 10.1016/j.joen.2007.07.042

Journal of Endodontics
Volume 33, Issue 11 , Pages 1329-1333 , November 2007