Journal of Endodontics
Volume 35, Issue 1 , Pages 23-29 , January 2009

Herpesviruses in Endodontic Pathoses: Association of Epstein-Barr Virus with Irreversible Pulpitis and Apical Periodontitis

  • Hong Li, DDS, MSc, PhD

      Affiliations

    • Department of Endodontology, Oregon Health & Science University, School of Dentistry, Portland, Oregon
    • ,
  • Vicky Chen, BS

      Affiliations

    • Department of Integrative Biosciences, Oregon Health & Science University, School of Dentistry, Portland, Oregon
    • Academic DMD Program, Oregon Health & Science University, School of Dentistry, Portland, Oregon
    • ,
  • Yanwen Chen, PhD

      Affiliations

    • Department of Integrative Biosciences, Oregon Health & Science University, School of Dentistry, Portland, Oregon
    • Academic DMD Program, Oregon Health & Science University, School of Dentistry, Portland, Oregon
    • ,
  • J. Craig Baumgartner, DDS, MSc, PhD

      Affiliations

    • Department of Endodontology, Oregon Health & Science University, School of Dentistry, Portland, Oregon
    • ,
  • Curtis A. Machida, PhD

      Affiliations

    • Department of Integrative Biosciences, Oregon Health & Science University, School of Dentistry, Portland, Oregon
    • Corresponding Author InformationAddress requests for reprints to Dr Curtis A. Machida, Department of Integrative Biosciences, Oregon Health & Science University, School of Dentistry, 611 SW Campus Drive, Portland, OR 97239

References 

  1. Sabeti M, Valles Y, Nowzari H, Simon JH, Kermani-Arab V, Slots J. Cytomegalovirus and Epstein-Barr virus DNA transcription in endodontic symptomatic lesions. Oral Microbiol Immunol. 2003;18:104–108
  2. Slots J, Nowzari H, Sabeti M. Cytomegalovirus infection in symptomatic periapical pathosis. Int Endod J. 2004;37:519–524
  3. Saygun I, Yapar M, Ozdemir A, Kubar A, Slots J. Human cytomegalovirus and Epstein-Barr virus type 1 in periodontal abscesses. Oral Microbiol Immunol. 2004;19:83–87
  4. Sample J, Young L, Martin B, et al. Epstein-Barr virus types 1 and 2 differ in their EBNA-3A, EBNA-3B, and EBNA-3C genes. J Virol. 1990;64:4084–4092
  5. Fafi-Kremer S, Morand P, Germi R, et al. A prospective follow-up of Epstein-Barr virus LMP1 genotypes in saliva and blood during infectious mononucleosis. J Infect Dis. 2005;192:2108–2111
  6. Yildirim S, Yapar M, Kubar A, Slots J. Human cytomegalovirus, Epstein-Barr virus and bone resorption-inducing cytokines in periapical lesions of deciduous teeth. Oral Microbiol Immunol. 2006;21:107–111
  7. Sabeti M, Slots J. Herpesviral-bacterial coinfection in periapical pathosis. J Endod. 2004;30:69–72
  8. Stashenko P, Teles R, D'Souza R. Periapical inflammatory responses and their modulation. Crit Rev Oral Biol Med. 1998;9:498–521
  9. Handysides RA, Jaramillo DE, Ingle JI. Examination, evaluation, diagnosis and treatment planning. In:  Ingle J,  Bakland L,  Baumgartner J editor. Ingle's Endodontics. 6th ed.. Hamiliton, CA: BC Decker, Inc; 2008;p. 526
  10. Saboia-Dantas CJ, Coutrin de Toledo LF, Sampaio-Filho HR, Siqueira JF. Herpesviruses in asymptomatic apical periodontitis lesions: an immunohistochemical approach. Oral Microbiol Immunol. 2007;22:320–325
  11. Andric M, Milasin J, Jovanovic T, Todorovic L. Human cytomegalovirus is present in odontogenic cysts. Oral Microbiol Immunol. 2007;22:347–351
  12. Sigurdsson A, Jacoway JR. Herpes zoster infection presenting as an acute pulpitis. Oral Surg Oral Med Oral Path Oral Radiol Endod. 1995;80:92–95
  13. Sunde PT, Olsen I, Enersen M, Beiske K, Grinde B. Human cytomegalovirus and Epstein-Barr virus in apical and marginal periodontitis: a role in pathology?. J Med Virol. 2008;80:1007–1011
  14. Chen T, Hudnall SD. Anatomical mapping of human herpesvirus reservoirs of infection. Mod Pathol. 2006;19:726–737
  15. Puchhammer-Stockl E, Gorzer I. Cytomegalovirus and Epstein-Barr virus subtypes—the search for clinical significance. J Clin Virol. 2006;36:239–248
  16. Sitki-Green D, Edwards RH, Webster-Cyriaque J, Raab-Traub N. Identification of Epstein-Barr virus strain variants in hairy leukoplakia and peripheral blood by use of a heteroduplex tracking assay. J Virol. 2002;76:9645–9656
  17. Sitki-Green D, Covington M, Raab-Traub N. Compartmentalization and transmission of multiple Epstein-Barr virus strains in asymptomatic carriers. J Virol. 2003;77:1840–1847
  18. Walling DM, Etienne W, Ray AJ, Flaitz CM, Nichols CM. Persistence and transition of Epstein-Barr virus genotypes in the pathogenesis of oral hairy leukoplakia. J Infect Dis. 2004;190:387–395
  19. Slots J, Saygun I, Sabeti M, Kubar A. Epstein-Barr virus in oral diseases. J Periodontal Res. 2006;41:235–244

 Supported by research funds from the American Association of Endodontists Foundation (fellowship award to HL), the Oregon Clinical and Translational Research Institute (OCTRI; grant number UL1 RR024140), the National Center for Research Resources (NCRR, a component of the National Institutes of Health [NIH]), and NIH Roadmap for Medical Research. VC was a 2007 OCTRI Student Research Fellow and is a 2008 OSLER Student Research Fellow. YC is a 2008 OCTRI Summer Research Fellow. JCB and CAM are supported with funds provided by the OHSU School of Dentistry.

PII: S0099-2399(08)00879-0

doi: 10.1016/j.joen.2008.09.017

Journal of Endodontics
Volume 35, Issue 1 , Pages 23-29 , January 2009

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