Journal of Endodontics
Volume 35, Issue 3 , Pages 321-328 , March 2009

Periodontal and Endodontic Regeneration

  • Jill D. Bashutski, MS
    • ,
  • Hom-Lay Wang, PhD

      Affiliations

    • Corresponding Author InformationAddress requests for reprints to Dr Hom-Lay Wang, Professor and Director of Graduate Periodontics, Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, 1011 N University Ave, Ann Arbor, MI 48109-1078.

References 

  1. Glossary of periodontal terms. Chicago: American Academy of Periodontology; 2001;
  2. Melcher AH. On the repair potential of periodontal tissues. J Periodontol. 1976;47:256–260
  3. Giannobile WV, Somerman MJ. Growth and amelogenin-like factors in periodontal wound healing: a systematic review. Ann Periodontol. 2003;8:193–204
  4. Nevins M, Giannobile WV, McGuire MK, et al. Platelet-derived growth factor stimulates bone fill and rate of attachment level gain: results of a large multicenter randomized controlled trial. J Periodontol. 2005;76:2205–2215
  5. Jung RE, Glauser R, Scharer P, Hammerle CH, Sailer HF, Weber FE. Effect of rhBMP-2 on guided bone regeneration in humans. Clin Oral Implants Res. 2003;14:556–568
  6. Heijl L, Heden G, Svardstrom G, Ostgren A. Enamel matrix derivative (EMDOGAIN) in the treatment of intrabony periodontal defects. J Clin Periodontol. 1997;24(Pt 2):705–714
  7. Engler WO, Ramfjord SP, Hiniker JJ. Healing following simple gingivectomy: a tritiated thymidine radioautographic study—I: epithelialization. J Periodontol. 1966;37:298–308
  8. Nyman S, Lindhe J, Karring T, Rylander H. New attachment following surgical treatment of human periodontal disease. J Clin Periodontol. 1982;9:290–296
  9. Caton JG, DeFuria EL, Polson AM, Nyman S. Periodontal regeneration via selective cell repopulation. J Periodontol. 1987;58:546–552
  10. Nyman S, Gottlow J, Lindhe J, Karring T, Wennstrom J. New attachment formation by guided tissue regeneration. J Periodontal Res. 1987;22:252–254
  11. Britain SK, Arx T, Schenk RK, Buser D, Nummikoski P, Cochran DL. The use of guided tissue regeneration principles in endodontic surgery for induced chronic periodontic-endodontic lesions: a clinical, radiographic, and histologic evaluation. J Periodontol. 2005;76:450–460
  12. Mellonig JT, Nevins M, Sanchez R. Evaluation of a bioabsorbable physical barrier for guided bone regeneration: part II—material and a bone replacement graft. Int J Periodontics Restorative Dent. 1998;18:129–137
  13. Schwartz Z, Mellonig JT, Carnes DL, et al. Ability of commercial demineralized freeze-dried bone allograft to induce new bone formation. J Periodontol. 1996;67:918–926
  14. Gouldin AG, Fayad S, Mellonig JT. Evaluation of guided tissue regeneration in interproximal defects: (II)—membrane and bone versus membrane alone. J Clin Periodontol. 1996;23:485–491
  15. Schallhorn RG. The use of autogenous hip marrow biopsy implants for bony crater defects. J Periodontol. 1968;39:145–147
  16. Dragoo MR, Sullivan HC. A clinical and histological evaluation of autogenous iliac bone grafts in humans: II—external root resorption. J Periodontol. 1973;44:614–625
  17. Ellegaard B, Karring T, Davies R, Loe H. New attachment after treatment of intrabony defects in monkeys. J Periodontol. 1974;45:368–377
  18. Hiatt WH, Schallhorn RG. Intraoral transplants of cancellous bone and marrow in periodontal lesions. J Periodontol. 1973;44:194–208
  19. Hiatt WH, Schallhorn RG, Aaronian AJ. The induction of new bone and cementum formation: IV—microscopic examination of the periodontium following human bone and marrow allograft, autograft and nongraft periodontal regenerative procedures. J Periodontol. 1978;49:495–512
  20. Mellonig JT, Bowers GM. Regenerating bone in clinical periodontics. J Am Dent Assoc. 1990;121:497–502
  21. Urist MR. Bone: formation by autoinduction. Science. 1965;150:893–899
  22. Altiere ET, Reeve CM, Sheridan PJ. Lyophilized bone allografts in periodontal intraosseous defects. J Periodontol. 1979;50:510–519
  23. Blumenthal N, Steinberg J. The use of collagen membrane barriers in conjunction with combined demineralized bone-collagen gel implants in human infrabony defects. J Periodontol. 1990;61:319–327
  24. Rummelhart JM, Mellonig JT, Gray JL, Towle HJ. A comparison of freeze-dried bone allograft and demineralized freeze-dried bone allograft in human periodontal osseous defects. J Periodontol. 1989;60:655–663
  25. Mellonig JT. Freeze-dried bone allografts in periodontal reconstructive surgery. Dent Clin North Am. 1991;35:505–520
  26. Pearson GE, Rosen S, Deporter DA. Preliminary observations on the usefulness of a decalcified, freeze-dried cancellous bone allograft material in periodontal surgery. J Periodontol. 1981;52:55–59
  27. Mellonig JT. Decalcified freeze-dried bone allograft as an implant material in human periodontal defects. Int J Periodontics Restorative Dent. 1984;4:40–55
  28. Reynolds MA, Aichelmann-Reidy ME, Branch-Mays GL, Gunsolley JC. The efficacy of bone replacement grafts in the treatment of periodontal osseous defects: a systematic review. Ann Periodontol. 2003;8:227–265
  29. Saad AY, Abdellatief EM. Healing assessment of osseous defects of periapical lesions associated with failed endodontically treated teeth with use of freeze-dried bone allograft. Oral Surg Oral Med Oral Pathol. 1991;71:612–617
  30. Brugnami F, Mellonig JT. Treatment of a large periapical lesion with loss of labial cortical plate using GTR: a case report. Int J Periodontics Restorative Dent. 1999;19:243–249
  31. Pinto VS, Zuolo ML, Mellonig JT. Guided bone regeneration in the treatment of a large periapical lesion: a case report. Pract Periodontics Aesthet Dent. 1995;7:76–82
  32. Tseng CC, Chen YH, Huang CC, Bowers GM. Correction of a large periradicular lesion and mucosal defect using combined endodontic and periodontal therapy: a case report. Int J Periodontics Restorative Dent. 1995;15:377–383
  33. Dragoo MR, Kaldahl WB. Clinical and histological evaluation of alloplasts and allografts in regenerative periodontal surgery in humans. Int J Periodontics Restorative Dent. 1983;3:8–29
  34. Bowers GM, Chadroff B, Carnevale R, et al. Histologic evaluation of new attachment apparatus formation in humans: part I. J Periodontol. 1989;60:664–674
  35. Bowers GM, Chadroff B, Carnevale R, et al. Histologic evaluation of new attachment apparatus formation in humans: part II. J Periodontol. 1989;60:675–682
  36. Yukna RA, Vastardis S. Comparative evaluation of decalcified and non-decalcified freeze-dried bone allografts in rhesus monkeys: I—histologic findings. J Periodontol. 2005;76:57–65
  37. Spector M. Anorganic bovine bone and ceramic analogs of bone mineral as implants to facilitate bone regeneration. Clin Plast Surg. 1994;21:437–444
  38. Sculean A, Stavropoulos A, Windisch P, Keglevich T, Karring T, Gera I. Healing of human intrabony defects following regenerative periodontal therapy with a bovine-derived xenograft and guided tissue regeneration. Clin Oral Investig. 2004;8:70–74
  39. Gupta R, Pandit N, Malik R, Sood S. Clinical and radiological evaluation of an osseous xenograft for the treatment of infrabony defects. J Can Dent Assoc. 2007;73:513
  40. Houser BE, Mellonig JT, Brunsvold MA, Cochran DL, Meffert RM, Alder ME. Clinical evaluation of anorganic bovine bone xenograft with a bioabsorbable collagen barrier in the treatment of molar furcation defects. Int J Periodontics Restorative Dent. 2001;21:161–169
  41. Taschieri S, Del Fabbro M, Testori T, Weinstein R. Efficacy of xenogeneic bone grafting with guided tissue regeneration in the management of bone defects after surgical endodontics. J Oral Maxillofac Surg. 2007;65:1121–1127
  42. Taschieri S, Del Fabbro M, Testori T, Saita M, Weinstein R. Efficacy of guided tissue regeneration in the management of through-and-through lesions following surgical endodontics: a preliminary study. Int J Periodontics Restorative Dent. 2008;28:265–271
  43. Meffert RM, Thomas JR, Hamilton KM, Brownstein CN. Hydroxylapatite as an alloplastic graft in the treatment of human periodontal osseous defects. J Periodontol. 1985;56:63–73
  44. Yukna RA, Harrison BG, Caudill RF, Evans GH, Mayer ET, Miller S. Evaluation of durapatite ceramic as an alloplastic implant in periodontal osseous defects: II—twelve month reentry results. J Periodontol. 1985;56:540–547
  45. Nevins ML, Camelo M, Nevins M, et al. Human histologic evaluation of bioactive ceramic in the treatment of periodontal osseous defects. Int J Periodontics Restorative Dent. 2000;20:458–467
  46. Apaydin ES, Torabinejad M. The effect of calcium sulfate on hard-tissue healing after periradicular surgery. J Endod. 2004;30:17–20
  47. Beck-Coon RJ, Newton CW, Kafrawy AH. An in vivo study of the use of a nonresorbable ceramic hydroxyapatite as an alloplastic graft material in periapical surgery. Oral Surg Oral Med Oral Pathol. 1991;71:483–488
  48. Katanec D, Pavelic B, Ivasovic Z. Efficiency of polylactide/polyglycolide copolymers bone replacements in bone defects healing measured by densitometry. Coll Antropol. 2004;28:331–336
  49. Yoshikawa G, Murashima Y, Wadachi R, Sawada N, Suda H. Guided bone regeneration (GBR) using membranes and calcium sulphate after apicectomy: a comparative histomorphometrical study. Int Endod J. 2002;35:255–263
  50. Gottlow J, Nyman S, Lindhe J, Karring T, Wennstrom J. New attachment formation in the human periodontium by guided tissue regeneration: case reports. J Clin Periodontol. 1986;13:604–616
  51. Dori F, Huszar T, Nikolidakis D, Arweiler NB, Gera I, Sculean A. Effect of platelet-rich plasma on the healing of intrabony defects treated with an anorganic bovine bone mineral and expanded polytetrafluoroethylene membranes. J Periodontol. 2007;78:983–990
  52. Cortellini P, Tonetti MS. Clinical performance of a regenerative strategy for intrabony defects: scientific evidence and clinical experience. J Periodontol. 2005;76:341–350
  53. Gottlow J, Nyman S, Karring T. Maintenance of new attachment gained through guided tissue regeneration. J Clin Periodontol. 1992;19:315–317
  54. Cortellini P, Pini Prato G, Tonetti MS. Periodontal regeneration of human infrabony defects: II—re-entry procedures and bone measures. J Periodontol. 1993;64:261–268
  55. Pecora G, Kim S, Celletti R, Davarpanah M. The guided tissue regeneration principle in endodontic surgery: one-year postoperative results of large periapical lesions. Int Endod J. 1995;28:41–46
  56. Couri CJ, Maze GI, Hinkson DW, Collins BH, Dawson DV. Medical grade calcium sulfate hemihydrate versus expanded polytetrafluoroethylene in the treatment of mandibular class II furcations. J Periodontol. 2002;73:1352–1359
  57. Garrett S, Polson AM, Stoller NH, et al. Comparison of a bioabsorbable GTR barrier to a non-absorbable barrier in treating human class II furcation defects: a multi-center parallel design randomized single-blind trial. J Periodontol. 1997;68:667–675
  58. Eickholz P, Kim TS, Holle R, Hausmann E. Long-term results of guided tissue regeneration therapy with non-resorbable and bioabsorbable barriers: I—class II furcations. J Periodontol. 2001;72:35–42
  59. Hugoson A, Ravald N, Fornell J, Johard G, Teiwik A, Gottlow J. Treatment of class II furcation involvements in humans with bioresorbable and nonresorbable guided tissue regeneration barriers: a randomized multi-center study. J Periodontol. 1995;66:624–634
  60. Brunel G, Piantoni P, Elharar F, Benque E, Marin P, Zahedi S. Regeneration of rat calvarial defects using a bioabsorbable membrane technique: influence of collagen cross-linking. J Periodontol. 1996;67:1342–1348
  61. Wang HL, O'Neal RB, Thomas CL, Shyr Y, MacNeil RL. Evaluation of an absorbable collagen membrane in treating Class II furcation defects. J Periodontol. 1994;65:1029–1036
  62. Christgau M, Schmalz G, Reich E, Wenzel A. Clinical and radiographical split-mouth-study on resorbable versus non-resorbable GTR-membranes. J Clin Periodontol. 1995;22:306–315
  63. Douthitt JC, Gutmann JL, Witherspoon DE. Histologic assessment of healing after the use of a bioresorbable membrane in the management of buccal bone loss concomitant with periradicular surgery. J Endod. 2001;27:404–410
  64. Steinberg AD, LeBreton G, Willey R, Mukherjee S, Lipowski J. Extravascular clot formation and platelet activation on variously treated root surfaces. J Periodontol. 1986;57:516–522
  65. de Andrade PF, de Souza SL, de Oliveira Macedo G, et al. Acellular dermal matrix as a membrane for guided tissue regeneration in the treatment of Class II furcation lesions: a histometric and clinical study in dogs. J Periodontol. 2007;78:1288–1299
  66. Vernino AR, Jones FL, Holt RA, Nordquist RE, Brand JW. Evaluation of the potential of a polylactic acid barrier for correction of periodontal defects in baboons: a clinical and histologic study. Int J Periodontics Restorative Dent. 1995;15:84–101
  67. Becker W, Becker BE, Berg L, Prichard J, Caffesse R, Rosenberg E. New attachment after treatment with root isolation procedures: report for treated Class III and Class II furcations and vertical osseous defects. Int J Periodontics Restorative Dent. 1988;8:8–23
  68. Garrett K, Kerr M, Hartwell G, O'Sullivan S, Mayer P. The effect of a bioresorbable matrix barrier in endodontic surgery on the rate of periapical healing: an in vivo study. J Endod. 2002;28:503–506
  69. Marin-Botero ML, Dominguez-Mejia JS, Arismendi-Echavarria JA, Mesa-Jaramillo AL, Florez-Moreno GA, Tobon-Arroyave SI. Healing response of apicomarginal defects to two guided tissue regeneration techniques in periradicular surgery: a double-blind, randomized-clinical trial. Int Endod J. 2006;39:368–377
  70. Teare JA, Ramoshebi LN, Ripamonti U. Periodontal tissue regeneration by recombinant human transforming growth factor-beta 3 in Papio ursinus. J Periodontal Res. 2008;43:1–8
  71. Cochran DL, Wozney JM. Biological mediators for periodontal regeneration. Periodontol 2000. 1999;19:40–58
  72. Papli R, Chen S. Surgical treatment of infrabony defects with autologous platelet concentrate or bioabsorbable barrier membrane: a prospective case series. J Periodontol. 2007;78:185–193
  73. Eickholz P, Krigar DM, Kim TS, Reitmeir P, Rawlinson A. Stability of clinical and radiographic results after guided tissue regeneration in infrabony defects. J Periodontol. 2007;78:37–46
  74. Saito E, Saito A, Kawanami M. Favorable healing following space creation in rhBMP-2-induced periodontal regeneration of horizontal circumferential defects in dogs with experimental periodontitis. J Periodontol. 2003;74:1808–1815
  75. Ripamonti U, Heliotis M, van den Heever B, Reddi AH. Bone morphogenetic proteins induce periodontal regeneration in the baboon (Papio ursinus). J Periodontal Res. 1994;29:439–445
  76. Bergenholtz G, Wikesjo UM, Sorensen RG, Xiropaidis AV, Wozney JM. Observations on healing following endodontic surgery in nonhuman primates (Macaca fascicularis): effects of rhBMP-2. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:116–125
  77. Dereka XE, Markopoulou CE, Vrotsos IA. Role of growth factors on periodontal repair. Growth Factors. 2006;24:260–267
  78. Regan JD, Gutmann JL, Iacopino AM, Diekwisch T. Response of periradicular tissues to growth factors introduced into the surgical site in the root-end filling material. Int Endod J. 1999;32:171–182
  79. Fagan MC, Miller RE, Lynch SE, Kao RT. Simultaneous augmentation of hard and soft tissues for implant site preparation using recombinant human platelet-derived growth factor: a human case report. Int J Periodontics Restorative Dent. 2008;28:37–43
  80. Schonfeld SE, Slavkin HC. Demonstration of enamel matrix proteins on root-analogue surfaces of rabbit permanent incisor teeth. Calcif Tissue Res. 1977;24:223–229
  81. Lindskog S. Formation of intermediate cementum: II—a scanning electron microscopic study of the epithelial root sheath of Hertwig in monkey. J Craniofac Genet Dev Biol. 1982;2:161–169
  82. Slavkin HC, Bessem C, Fincham AG, et al. Human and mouse cementum proteins immunologically related to enamel proteins. Biochim Biophys Acta. 1989;991:12–18
  83. Lin S, Mayer Y. Treatment of a large periradicular lesion of endodontic origin around a dental implant with enamel matrix protein derivative. J Periodontol. 2007;78:2385–2388
  84. Bhatnagar RS, Qian JJ, Wedrychowska A, Sadeghi M, Wu YM, Smith N. Design of biomimetic habitats for tissue engineering with P-15, a synthetic peptide analogue of collagen. Tissue Eng. 1999;5:53–65
  85. Yukna RA, Krauser JT, Callan DP, Evans GH, Cruz R, Martin M. Thirty-six month follow-up of 25 patients treated with combination anorganic bovine-derived hydroxyapatite matrix (ABM)/cell-binding peptide (P-15) bone replacement grafts in human infrabony defects: I—clinical findings. J Periodontol. 2002;73:123–128
  86. Miller SC, Hunziker J, Mecham M, Wronski TJ. Intermittent parathyroid hormone administration stimulates bone formation in the mandibles of aged ovariectomized rats. J Dent Res. 1997;76:1471–1476
  87. Barros SP, Silva MA, Somerman MJ, Nociti FH. Parathyroid hormone protects against periodontitis-associated bone loss. J Dent Res. 2003;82:791–795
  88. Jung RE, Cochran DL, Domken O, et al. The effect of matrix bound parathyroid hormone on bone regeneration. Clin Oral Implants Res. 2007;18:319–325
  89. Jung RE, Hammerle CH, Kokovic V, Weber FE. Bone regeneration using a synthetic matrix containing a parathyroid hormone peptide combined with a grafting material. Int J Oral Maxillofac Implants. 2007;22:258–266
  90. Tobon SI, Arismendi JA, Marin ML, Mesa AL, Valencia JA. Comparison between a conventional technique and two bone regeneration techniques in periradicular surgery. Int Endod J. 2002;35:635–641
  91. Laurell L, Gottlow J, Zybutz M, Persson R. Treatment of intrabony defects by different surgical procedures: a literature review. J Periodontol. 1998;69:303–313
  92. Caton J, Nyman S, Zander H. Histometric evaluation of periodontal surgery: II—connective tissue attachment levels after four regenerative procedures. J Clin Periodontol. 1980;7:224–231
  93. Murphy KG, Gunsolley JC. Guided tissue regeneration for the treatment of periodontal intrabony and furcation defects: a systematic review. Ann Periodontol. 2003;8:266–302
  94. Needleman IG, Worthington HV, Giedrys-Leeper E, Tucker RJ. Guided tissue regeneration for periodontal infra-bony defects. Cochrane Database Syst Rev. 2006;(2):CD001724
  95. Del Fabbro M, Taschieri S, Testori T, Francetti L, Weinstein RL. Surgical versus non-surgical endodontic re-treatment for periradicular lesions. Cochrane Database Syst Rev. 2007;(3):CD005511
  96. Tonetti MS, Pini-Prato G, Cortellini P. Effect of cigarette smoking on periodontal healing following GTR in infrabony defects: a preliminary retrospective study. J Clin Periodontol. 1995;22:229–234
  97. Cortellini P, Pini-Prato G, Tonetti M. Periodontal regeneration of human infrabony defects (V): effect of oral hygiene on long-term stability. J Clin Periodontol. 1994;21:606–610
  98. Machtei EE, Cho MI, Dunford R, Norderyd J, Zambon JJ, Genco RJ. Clinical, microbiological, and histological factors which influence the success of regenerative periodontal therapy. J Periodontol. 1994;65:154–161
  99. Taschieri S, Testori T, Azzola F, Del Fabbro M, Valentini P. [Guided-tissue regeneration in endodontic surgery]. Rev Stomatol Chir Maxillofac. 2008 Sep;109(4):213–217
  100. Renvert S, Garrett S, Nilveus R, Chamberlain AD, Egelberg J. Healing after treatment of periodontal intraosseous defects: VI—factors influencing the healing response. J Clin Periodontol. 1985;12:707–715
  101. Steffensen B, Webert HP. Relationship between the radiographic periodontal defect angle and healing after treatment. J Periodontol. 1989;60:248–254
  102. Novaes AB, Palioto DB, de Andrade PF, Marchesan JT. Regeneration of class II furcation defects: determinants of increased success. Braz Dent J. 2005;16:87–97
  103. Tonetti MS, Pini-Prato G, Cortellini P. Periodontal regeneration of human intrabony defects: IV—determinants of healing response. J Periodontol. 1993;64:934–940
  104. Wang HL, Boyapati L. “PASS” principles for predictable bone regeneration. Implant Dent. 2006;15:8–17

PII: S0099-2399(08)01112-6

doi: 10.1016/j.joen.2008.11.023

Journal of Endodontics
Volume 35, Issue 3 , Pages 321-328 , March 2009

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