Journal of Endodontics
Volume 36, Issue 2 , Pages 190-202, February 2010

Mineral Trioxide Aggregate: A Comprehensive Literature Review—Part II: Leakage and Biocompatibility Investigations

  • Mahmoud Torabinejad, DMD, MSD, PhD

      Affiliations

    • Department of Endodontics, School of Dentistry, Loma Linda University, Loma Linda, California
    • Corresponding Author InformationAddress requests for reprints to Mahmoud Torabinejad, DMD, MSD, PhD, Professor and Director, Endodontic Residency Program, Department of Endodontics, School of Dentistry, Loma Linda University, Loma Linda, CA 92350.
    • ,
  • Masoud Parirokh, DMD, MS

      Affiliations

    • Department of Endodontics, School of Dentistry, Oral and Dental Diseases Research Center, Neuroscience Research Center, Iranian Center for Endodontic Research, Kerman University of Medical Sciences, Kerman, Iran

Abstract 

Introduction

Mineral trioxide aggregate (MTA) was developed because existing materials did not have the ideal characteristics for orthograde or retrograde root-end fillings. MTA has been recommended primarily as a root-end filling material, but it has also been used in pulp capping, pulpotomy, apical barrier formation in teeth with open apexes, repair of root perforations, and root canal filling. Part I of this literature review presented a comprehensive list of articles regarding the chemical and physical properties as well as the antibacterial activity of MTA. The purpose of part II of this review is to present a comprehensive list of articles regarding the sealing ability and biocompatibility of this material.

Methods

A review of the literature was performed by using electronic and hand-searching methods for the sealing ability and biocompatibility of MTA from November 1993–September 2009.

Results

Numerous studies have investigated the sealing ability and biocompatibility of MTA.

Conclusions

On the basis of available evidence it appears that MTA seals well and is a biocompatible material.

Key Words: Apical plug, biocompatibility, cytokine production, marginal adaptation, mineral trioxide aggregate, MTA, root-end filling, sealing ability, signaling molecule

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PII: S0099-2399(09)00770-5

doi:10.1016/j.joen.2009.09.010

Journal of Endodontics
Volume 36, Issue 2 , Pages 190-202, February 2010

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