Journal of Endodontics
Volume 36, Issue 2 , Pages 256-259 , February 2010

The MAP Kinase Pathway Is Involved in Odontoblast Stimulation via p38 Phosphorylation

  • Stephane Simon, DDS, MPhil

      Affiliations

    • INSERM, Centre de Recherche des Cordeliers, Paris, France
    • Université Pierre et Marie Curie-Paris 6, Paris, France
    • Université Paris Descartes, Paris, France
    • Team 5-Molecular Oral Physiopathology, Université Paris Diderot, Paris, France
    • Oral Biology, School of Dentistry, University of Birmingham, Birmingham, United Kingdom
    • Corresponding Author InformationAddress requests for reprints to Dr Stéphane Simon, Laboratoire de Physiopathologie Orale Moléculaire, INSERM, UMR S 872, Escalier B, 15-21 rue de l'Ecole de Médecine, 75006 Paris, France.
    • ,
  • Anthony J. Smith

      Affiliations

    • Oral Biology, School of Dentistry, University of Birmingham, Birmingham, United Kingdom
    • ,
  • Ariane Berdal, PhD

      Affiliations

    • INSERM, Centre de Recherche des Cordeliers, Paris, France
    • Université Pierre et Marie Curie-Paris 6, Paris, France
    • Université Paris Descartes, Paris, France
    • Team 5-Molecular Oral Physiopathology, Université Paris Diderot, Paris, France
    • ,
  • Philip J. Lumley, PhD

      Affiliations

    • Oral Biology, School of Dentistry, University of Birmingham, Birmingham, United Kingdom
    • ,
  • Paul R. Cooper, PhD

      Affiliations

    • Oral Biology, School of Dentistry, University of Birmingham, Birmingham, United Kingdom

References 

  1. Goldberg M, Smith AJ. Cells and extracellular matrices of dentin and pulp: a biological basis for repair and tissue engineering. Crit Rev Oral Biol Med. 2004;15:13–27
  2. Smith AJ, Cassidy N, Perry H, et al. Reactionary dentinogenesis. Int J Dev Biol. 1995;39:273–280
  3. Mjor IA. Dentin and pulp. In:  Raton B editors. Reaction Patterns in Human Teeth. CRC Press; 1983;p. 63–156
  4. Smith AJ, Lesot H. Induction and regulation of crown dentinogenesis: embryonic events as a template for dental tissue repair?. Crit Rev Oral Biol Med. 2001;12:425–437
  5. Cam Y, Lesot H, Colosetti P, et al. Distribution of transforming growth factor beta1-binding proteins and low-affinity receptors during odontoblast differentiation in the mouse. Arch Oral Biol. 1997;42:385–391
  6. Lesot H, Lisi S, Peterkova R, et al. Epigenetic signals during odontoblast differentiation. Adv Dent Res. 2001;15:8–13
  7. Begue-Kirn C, Smith AJ, Loriot M, et al. Comparative analysis of TGF beta s, BMPs, IGF1, msxs, fibronectin, osteonectin and bone sialoprotein gene expression during normal and in vitro-induced odontoblast differentiation. Int J Dev Biol. 1994;38:405–420
  8. Begue-Kirn C, Smith AJ, Ruch JV, et al. Effects of dentin proteins, transforming growth factor beta 1 (TGF beta 1) and bone morphogenetic protein 2 (BMP2) on the differentiation of odontoblast in vitro. Int J Dev Biol. 1992;36:491–503
  9. Cassidy N, Fahey M, Prime SS, et al. Comparative analysis of transforming growth factor-beta isoforms 1-3 in human and rabbit dentine matrices. Arch Oral Biol. 1997;42:219–223
  10. Graham L, Cooper PR, Cassidy N, et al. The effect of calcium hydroxide on solubilisation of bio-active dentine matrix components. Biomaterials. 2006;27:2865–2873
  11. Tomson PL, Grover LM, Lumley PJ, et al. Dissolution of bio-active dentine matrix components by mineral trioxide aggregate. J Dent. 2007;35:636–642
  12. Smith AJ, Tobias RS, Cassidy N, et al. Odontoblast stimulation in ferrets by dentine matrix components. Arch Oral Biol. 1994;39:13–22
  13. Sloan AJ, Smith AJ. Stimulation of the dentine-pulp complex of rat incisor teeth by transforming growth factor-beta isoforms 1-3 in vitro. Arch Oral Biol. 1999;44(2):149–156
  14. Duque C, Hebling J, Smith AJ, et al. Reactionary dentinogenesis after applying restorative materials and bioactive dentin matrix molecules as liners in deep cavities prepared in nonhuman primate teeth. J Oral Rehabil. 2006;33:452–461
  15. Simon S, Smith AJ, Berdal A, et al. Molecular Characterization of young and mature odontoblasts. Bone. 2009;(in press)
  16. Simon S, Smith AJ, Lumley PJ, Berdal A, Smith G, Finney S, et al. Molecular characterization of young and mature odontoblasts. Bone. 2009;45:693–703
  17. Hanks CT, Fang D, Sun Z, et al. Dentin-specific proteins in MDPC-23 cell line. Eur J Oral Sci. 1998;106(suppl 1):260–266
  18. Geiger PC, Wright DC, Han DH, et al. Activation of p38 MAP kinase enhances sensitivity of muscle glucose transport to insulin. Am J Physiol Endocrinol Metab. 2005;288:E7828
  19. Wang FM, Hu T, Tan H, et al. p38 Mitogen-activated protein kinase affects transforming growth factor-beta/Smad signaling in human dental pulp cells. Mol Cell Biochem. 2006;291:49–54
  20. Unterbrink A, O'Sullivan M, Chen S, et al. TGF beta-1 downregulates DMP-1 and DSPP in odontoblasts. Connect Tissue Res. 2002;43:354–358
  21. D'Souza RN, Cavender A, Dickinson D, et al. TGF-beta1 is essential for the homeostasis of the dentin-pulp complex. Eur J Oral Sci. 1998;106(suppl 1):185–191
  22. D'Souza RN, Flanders K, Butler WT. Colocalization of TGF-beta 1 and extracellular matrix proteins during rat tooth development. Proc Finn Dent Soc. 1992;88(suppl 1):419–426
  23. Zhao Q, Chen N, Wang WM, et al. Effect of transforming growth factor-beta on activity of connective tissue growth factor gene promoter in mouse NIH/3T3 fibroblasts. Acta Pharmacol Sin. 2004;25:485–489
  24. Ning W, Song R, Li C, et al. TGF-beta1 stimulates HO-1 via the p38 mitogen-activated protein kinase in A549 pulmonary epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2002;283:L1094–L1102
  25. Tziafas D, Smith AJ, Lesot H. Designing new treatment strategies in vital pulp therapy. J Dent. 2000;28:77–92

PII: S0099-2399(09)00779-1

doi: 10.1016/j.joen.2009.09.019

Journal of Endodontics
Volume 36, Issue 2 , Pages 256-259 , February 2010

Article Tools

* Image Usage & Resolution