Effect of Mineral Trioxide Aggregates and Portland Cements on Inflammatory Cells
published online 08 March 2010.
Abstract
Introduction
Recently, some studies have compared mineral trioxide aggregate (MTA) with Portland cements, concluding that the principal ingredients of Portland cements are similar to those of MTA. The purpose of the present study was to evaluate the effect of gray MTA, white MTA, and gray and white Portland cements on inflammatory cells in rats.
Methods
Fresh mixtures mixed with distilled water were placed in polyethylene tubes, which were implanted in the dorsal subcutaneous connective tissue of 60 Sprague-Dawley rats along with empty tubes as controls. Tissue specimens were collected after the rats were sacrificed after 7, 15, 30, 60, and 90 days. The specimens were fixed, stained, processed, and histologically evaluated under a light microscope. Inflammatory reactions were classified as grade 0: without inflammatory cells, grade I: sporadic infiltration of inflammatory cells, grade II: moderate infiltration (<25 cells), grade III: dense and severe infiltration (25-125 cells), and grade IV: very dense and severe infiltration (>125 cells). Data were analyzed with the nonparametric (two factor) analysis of variance and Kruskal-Wallis H-test.
Results
All the groups showed grade III inflammation after 7 and 15 days; there was a decrease in the inflammatory process after 30, 60, and 90 days. After 90 days, gray MTA, white MTA, and control groups had grade 0 inflammatory process, but gray Portland cement and white Portland cement groups showed grade 0 to grade I inflammatory processes.
Conclusion
MTAs were more biocompatible; however, more studies are required.
∗Department of Endodontics, Tabriz University of Medical Sciences, Tabriz, Iran
†Department of Histology, Tabriz University of Medical Sciences, Tabriz, Iran
‡Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Address requests for reprints to Dr Hadi Mokhtari, DDS, MSc, Department of Endodontics, Tabriz Dental School, Tabriz University of Medical Sciences, Tabriz, Iran.
Supported by Tabriz University of Medical Sciences.
ABSTRACT