Periapical granulation tissue consists of vasculature of varying sizes and types,
infiltrating cells, and other stromal elements. We examined the differential expression
of endothelial and stroma antigens in this tissue to determine their tissue distribution
in order to obtain hints on their functions. Some of the antigens examined were present
only in the endothelial lining of vasculature, including high endothelial venules
(e.g. CD31 and CD105), whereas others were more widely expressed by both vascular
and stromal elements (e.g. CD29, CD63, CD44, and CD151). Immunohistochemical analysis
using monoclonal antibodies specific to certain tissue compartments revealed the tissue
architecture more precisely and the expression of certain antigens in the tissue suggested
special roles for these antigens. Tissue distribution of CD63, CD143, CD147, and CD151
in periapical granulation tissue is first reported in the present study.
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© 2000 The American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
