Abstract
Human beta-defensins (hBDs) are antimicrobial peptides that play an important role
in the innate host defense against bacterial invasion, contribute to promotion of
adaptive immune responses, and show chemotactic activities. The aim of this study
was to compare the gene expression of hBD-1, -2, -3, and -4 in healthy teeth and teeth
with pulpitis. Samples of healthy and inflamed dental pulps were obtained from extracted
third molars and during treatment of teeth with pulpitis. Gene expression was assessed
by using reverse transcriptase reaction and real-time polymerase chain reaction. HBD-2
and hBD -3 were only weakly expressed in healthy and inflamed pulps. In contrast,
the expression of hBD-1 and hBD -4 was significantly increased in inflamed compared
with healthy pulps. These results suggest that hBD-1 and hBD-4 might play a role in
the pulpal host defense.
Key Words
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Article info
Footnotes
Drs Paris and Wolgin contributed equally to this study.
Identification
Copyright
© 2009 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
