This study examined the ability of two versions of QMix, an experimental antimicrobial irrigant, on removal of canal wall smear layers and debris using an open canal design.
Cleaned and shaped single-rooted human root canals were irrigated with NaOCl as the initial irrigant and one of the following as the final irrigant: (1) QMix I (pH = 8), (2) QMix II (pH = 7.5), (3) distilled water, (4) 17% EDTA, and (5) BioPure MTAD (Dentsply Tulsa Dental Specialties, Tulsa, OK). Smear and debris scores were evaluated in the coronal, middle, and apical thirds of longitudinally fractured canal spaces using scanning electron microscopy and analyzed using Cochran-Mantel-Haenszel statistic.
Smear scores, when the overall canal was considered, differences were observed among groups except groups 1 versus 4 and groups 2 versus 4. After adjusting for canal levels, all groups differed significantly from each other (p < 0.005) with the exception of groups 2 versus 5. For the debris scores, no significant difference was observed among the treatment groups when the overall canal was considered and after adjusting for the effect of canal level.
Within the limitations of an open-canal design, the two experimental QMix versions are as effective as 17% EDTA in removing canal wall smear layers after the use of 5.25% NaOCl as the initial rinse.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Journal of Endodontics
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Bacteriologic evaluation of the efficacy of mechanical root canal instrumentation in endodontic therapy.Scand J Dent Res. 1981; 89: 321-328
- Mechanical reduction of the bacterial population in the root canal by three instrumentation techniques.J Endod. 1999; 25: 332-335
- Antimicrobial efficacy of various root canal preparation techniques: an in vitro comparative study.J Endod. 2002; 28: 603-605
- The morphology of the prepared root canal: a study utilizing infectable silicone.Oral Surg Oral Med Oral Pathol. 1972; 34: 642-648
- Effects of four Ni-Ti preparation techniques on root canal geometry assessed by micro computed tomography.Int Endod J. 2001; 34: 221-230
- The efficacy of several irrigating solutions for endodontics: a scanning electron microscopic study.Oral Surg Oral Med Oral Pathol. 1985; 52: 197-204
- Principles and Practices of Endodontics.2nd ed. WB Saunders, Philadelphia1996
- Bacterial retention in canal walls in vitro: effect of smear layer.J Endod. 1994; 20: 78-82
- Effect of smear layer removal on the diffusion permeability of human roots.J Endod. 1994; 20: 83-86
- Clinical implications of the smear layer in endodontics: a review.Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002; 94: 658-666
- The role of environmental changes on monospecies biofilm formation on root canal wall by Enterococcus faecalis.J Endod. 2005; 31: 867-872
- Effect of smear layer on sealing ability of canal obturation: a systematic review and meta-analysis.J Endod. 2007; 33: 96-105
- A scanning electron microscopic evaluation of four root canal irrigation regimens.J Endod. 1987; 13: 147-157
- Root canal irrigants.J Endod. 2006; 32: 389-398
- The antimicrobial effect of MTAD: an in vitro investigation.J Endod. 2003; 29: 400-403
- In vitro antimicrobial effect of MTAD and NaOCl.J Endod. 2003; 29: 450-452
- Effect of MTAD on Enterococcus faecalis-contaminated root canals of extracted human teeth.J Endod. 2003; 29: 576-579
- The antimicrobial effect of Biopure MTAD on eight strains of Enterococcus faecalis: an in vitro investigation.J Endod. 2007; 33: 1352-1354
- An in vitro comparison of the antimicrobial effects of various endodontic medicaments on Enterococcus faecalis.J Endod. 2007; 33: 567-569
- A new solution for the removal of the smear layer.J Endod. 2003; 29: 170-175
- The effect of various concentrations of sodium hypochlorite on the ability of MTAD to remove the smear layer.J Endod. 2003; 29: 233-239
- A comparison of the antimicrobial efficacy of NaOCl/Biopure MTAD versus NaOCl/EDTA against Enterococcus faecalis.J Endod. 2006; 32: 652-655
- Comparison of the antimicrobial efficacy of 1.3% NaOCl/BioPure MTAD to 5.25% NaOCl/15% EDTA for root canal irrigation.J Endod. 2007; 33: 48-51
- Reduction in antimicrobial substantivity of MTAD after initial sodium hypochlorite irrigation.J Endod. 2006; 32: 970-975
- The effect of exposure to irrigant solutions on apical dentin biofilms in vitro.J Endod. 2006; 32: 434-437
- Comparative evaluation of endodontic irrigants against Enterococcus faecalis biofilms.J Endod. 2006; 32: 527-531
- Comparative evaluation of antimicrobial efficacy of sodium hypochlorite, MTAD, and Tetraclean against Enterococcus faecalis biofilm.J Endod. 2007; 33: 852-855
- Biofilms in endodontic infections.Endod Topics. 2004; 9: 27-36
- Response to alkaline stress by root canal bacteria in biofilms.Int Endod J. 2007; 40: 344-355
- Dentin demineralization when subjected to BioPure MTAD: a longitudinal and quantitative assessment.J Endod. 2007; 33: 1364-1368
- The effect of vapor lock on root canal debridement using a side-vented needle for positive-pressure irrigant delivery.J Endod. 2010; 36: 745-750
- Microporous, demineralized collagen matrices in intact radicular dentin created by commonly used calcium-depleting endodontic irrigants.J Endod. 2007; 33: 1086-1090
- Review of contemporary irrigant agitation techniques and devices.J Endod. 2009; 35: 791-804
- Efficacy of different irrigation and activation systems on the penetration of sodium hypochlorite into simulated lateral canals and up to working length: an in vitro study.J Endod. 2010; 36: 1216-1221
- Mechanical effectiveness of root canal irrigation.J Endod. 1983; 9: 475-479
Supported by Dentsply Tulsa Dental Specialties.
Dr Khaled Khechen is Clinical Research Manager of Dentsply Tulsa Dental Specialties.
© 2011 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.