Abstract
Introduction
External apical root resorption (EARR) is a frequent iatrogenic effect of orthodontic
treatment. The way root-filled teeth respond to orthodontic forces with respect to
EARR has been reported as varying widely between individuals. Genetic variants in
the interleukin-1 gene have been associated with an increased risk of experiencing
postorthodontic EARR on vital teeth. The objective of this study is to determine whether
variants in the interleukin-1 gene have a positive or negative influence on EARR on
teeth that have been endodontically treated.
Methods
Ninety-three orthodontic patients underwent genetic screening for 2 single nucleotide
polymorphisms (rs1800587, rs1143634) in the IL1 gene cluster. Subjects were divided into 2 groups depending on the presence (affected
group) or absence (control group) of more than 2 mm of EARR on root-filled teeth after
orthodontic treatment as shown by radiography. Logistic regression analysis was used
to obtain adjusted estimates of EARR and IL1 polymorphisms. Allele frequencies, genotype distributions, and adjusted odds ratios
were also calculated (95% confidence interval).
Results
No positive or negative statistical association was found between postorthodontic
treatment EARR in root-filled teeth and genetic variations in IL1A (P > .05). A direct relationship was found for the IL1B gene in the comparative analysis of homozygous subjects (2/2[TT]) and (1/1[CC]),
which led to an increased risk of experiencing postorthodontic treatment EARR in root-filled
teeth (odds ratio = 11.59; P = .006; confidence interval, 95%) and (odds ratio = 2.54; P = .035; confidence interval, 95%), respectively.
Conclusions
The development of EARR in subjects with root-filled teeth who undergo orthodontic
treatment might be attributable to genetic variations in the interleukin-1β gene (rs1143634).
Key Words
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Article info
Publication history
Published online: January 24, 2012
Footnotes
Supported by national grants to the CTS35 Research Group. Also supported by Ministerio de Ciencia e Innovación, Instituto de Salud Carlos III—co-financed by European Development Regional Fund “A Way to Achieve Europe” ERDF, Spanish Network for the Research in Infectious Diseases (REIPI RD06/0008).
Identification
Copyright
© 2012 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
