Abstract
Introduction
Control of postoperative discomfort might enhance the patient’s quality of life and
treatment acceptance. The aim of the present randomized single-blind study was to
evaluate whether the use of platelet concentrate during endodontic surgery might have a
favorable impact on pain and other factors related to patient’s quality of life during
the first week after surgery.
Methods
Eighteen patients with periapical lesion were treated with modern endodontic surgical
procedure (control group). In another 18 patients, in adjunct to surgical procedure,
platelet concentrate was applied on the root end in liquid form, within the bone defect
in clot form, and over the suture in liquid form (test group). All patients completed
a questionnaire for evaluation of main symptoms and daily activities during the first
week after surgery. The outcomes of the questionnaires of the 2 groups were statistically
compared.
Results
The test group showed significantly less pain and swelling, fewer analgesics taken,
and improved functional activities as compared with the control group.
Conclusions
The adjunct of platelet concentrate to the endodontic surgical procedure produced
significant beneficial effect to patients’ quality of life during the early postoperative
stage.
Key Words
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of EndodonticsAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Surgical endodontics.in: Cohen S. Burns R. Pathways of the pulp. 7th ed. Mosby Inc, St Louis, MO1998: 608-656
- Modern endodontic practice: instruments and techniques.Dent Clin North Am. 2004; 48: 1-9
- Papilla base incision: a new approach to recession-free healing of the interdental papilla after endodontic surgery.Int Endod J. 2002; 35: 453-460
- Comparison of papilla healing following sulcular full-thickness flap and papilla base flap in endodontic surgery.Int Endod J. 2003; 36: 653-659
- Comparison of long term papilla healing following sulcular full thickness flap and papilla base flap in endodontic surgery.Int Endod J. 2004; 37: 687-693
- Soft tissue management in endodontic surgery.J Endod. 2005; 31: 4-16
- Papilla healing following sulcular full thickness flap in endodontic surgery.Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004; 98: 365-369
- Changes of periodontal parameters following apical surgery: prospective clinical study of three incision techniques.Int Endod J. 2007; 40: 959-969
- Success, failure, and prognosis in periradicular surgery.in: Gutmann J. Harrison J.W. Surgical endodontics. 1st ed. Blackwell Scientific Publications, Boston, MA1991: 362-368
- Postoperative pain after apicoectomy: a clinical investigation.Int Endod J. 1986; 19: 242-247
- The effect of two different local anaesthetic solutions on pain experience following apicectomy.Br Dent J. 1993; 175: 410-413
- Use of dental operating microscope in endodontic surgery.Oral Surg Oral Med Oral Pathol. 1993; 75: 751-758
- Analysis of postoperative symptoms following surgical endodontic treatment.Quintessence Int. 2003; 34: 756-760
- Comparison of quality of life after surgical endodontic treatment using two techniques: a prospective study.Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005; 99: 367-371
- Quality of life after microscopic periradicular surgery using two different incision techniques: a randomized clinical study.Int Endod J. 2009; 42: 360-367
- Microscopic periradicular surgery: perioperative predictors for postoperative clinical outcomes and quality of life assessment.J Endod. 2007; 33: 239-244
- Platelet-rich plasma: growth factor enhancement for bone grafts.Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998; 85: 638-646
- Platelet concentrate: a strategy for accelerating and improving bone regeneration.in: Davies J.E. Bone engineering. Em Squared Inc, Toronto, Ontario, Canada2001: 447-453
- The use of plasma-rich growth factors (PRGF) in oral surgery.Pract Proced Aesthet Dent. 2001; 13: 487-493
- Autologous platelets as a source of proteins for healing and tissue regeneration.Thromb Haemost. 2004; 91: 4-15
- Influence of the application of platelet-enriched plasma in oral mucosal wound healing.Clin Oral Implants Res. 2007; 18: 133-139
- The influence of platelet-rich plasma on the healing of extraction sockets: an explorative randomised clinical trial.Eur J Oral Implantol. 2010; 3: 121-134
- Potential for osseous regeneration of platelet rich plasma: a comparative study in mandibular third molar sockets.Indian J Dent Res. 2004; 15: 133-136
- The impact of plasma rich in growth factors on clinical and biological factors involved in healing processes after third molar extraction.J Biomed Mater Res A. 2010; 95: 741-746
- Is autologous platelet concentrate beneficial for post-extraction socket healing? a systematic review.Int J Oral Maxillofac Surg. 2011; 40: 891-900
- Effect of autologous growth factors in maxillary sinus augmentation: a systematic review.Clin Impl Dent Rel Res. 2011; https://doi.org/10.1111/j.1708-8208.2011.00343.x
- Treatment of through and through bone lesion using autologous growth factors and xenogeneic bone graft: a case report.Oral Maxillofac Surg. 2012; 16: 57-64
- The effects of an immediately pre-surgical chlorhexidine oral rinse on the bacterial contaminants of bone debris collected during dental implant surgery.Clin Oral Implants Res. 2002; 13: 20-29
- Posterior endodontic surgery: anatomical considerations and clinical techniques.Int Endod J. 1985; 18: 8-34
- Therapeutic efficacy of cold therapy after intraoral surgical procedures: a literature review.J Periodontol. 2007; 78: 790-800
- Developing a measure of patient perceptions of short-term outcomes of third molar surgery.J Oral Maxillofac Surg. 1996; 54: 1402-1408
- Platelet-rich plasma: clinical applications in dentistry.J Am Dent Assoc. 2002; 133: 1383-1386
- Platelets stimulate proliferation of bone cells: involvement of platelet-derived growth factor, microparticles and membranes.Clin Oral Implants Res. 2002; 13: 529-535
- Bone graft physiology with use of platelet-rich plasma and hyperbaric oxygen.in: Jensen O. The sinus bone graft. Quintessence, New Malden, Surrey, United Kingdom1999: 183-189
- Growth stimulation of human osteoblast-like cells by thrombocyte concentrates in vitro.Mund Kiefer Gesichtschir. 2002; 6: 168-174
- Periodontal tissue engineering by growth factors.Bone. 1996; 19: 23S-37S
- The use of platelet-rich plasma in bone reconstruction therapy.Biomaterials. 2009; 30: 4956-4966
- Growth factor stimulation of bone healing: effects on osteoblasts, osteotomies, and implants fixation.Acta Orthop Scand Suppl. 1998; 283: 2-37
- Antibacterial effect of autologous platelet gel enriched with growth factors and other active substances: an in vitro study.J Bone Joint Surg Br. 2007; 89: 417-420
- Antimicrobial peptides from human platelets.Infect Immun. 2002; 70: 6524-6533
- Current applications of platelet gels in facial plastic surgery.Facial Plast Surg. 2002; 18: 27-33
M, Bielecki T, Gazdzik TS. Current opinion about using the platelet-rich gel in orthopaedics and trauma surgery. Ortop Traumatol Rehabil 2007;9:227–38.
- Effects of platelet-rich plasma on sinus bone graft: meta-analysis.J Periodontol. 2011; 82: 660-667
- Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus.Cochrane Database Syst Rev. 2010; 21: CD008397
- The adjunctive use of platelet-rich plasma in the therapy of periodontal intraosseous defects: a systematic review.J Periodontal Res. 2010; 45: 428-443
- Efficacy and safety of the use of autologous plasma rich in platelets for tissue regeneration: a systematic review.Transfusion. 2009; 49: 44-56
- Effect of platelet-rich plasma on bone regeneration in dentistry: a systematic review.Clin Oral Implants Res. 2008; 19: 539-545
- Clinical outcomes with bioactive agents alone or in combination with grafting or guided tissue regeneration.J Clin Periodontol. 2008; 35: 117-135
- A comparative study of root coverage with connective tissue and platelet concentrate grafts: 8-month results.J Periodontol. 2004; 75: 1678-1687
- Platelet-rich plasma: growth factors and pro- and anti-inflammatory properties.J Periodontol. 2007; 78: 661-669
- Use of platelet-rich plasma in the management of oral biphosphonate-associated osteonecrosis of the jaw: a report of 2 cases.J Oral Implantol. 2007; 33: 371-382
- Inhibition of alveolar osteitis in mandibular tooth extraction sites using platelet-rich plasma.J Oral Implantol. 2007; 33: 116-121
- Platelet rich plasma to facilitate wound healing following tooth extraction.J Oral Implantol. 2010; 36: 11-23
- Potential for osseous regeneration of platelet-rich plasma: a comparative study in mandibular third molar sockets.Indian J Dent Res. 2004; 15: 133-136
- Effects of platelet concentrate on palatal wound healing after connective tissue graft harvesting.J Periodontol. 2007; 78: 601-610
- Sphingolipids in inflammation: pathological implications and potential therapeutic targets.Br J Pharmacol. 2009; 158: 982-993
- Regulation of vascular cell function by bioactive lysophospholipids.J Thromb Haemost. 2009; 7: 38-43
- Sphingosine-1-phosphate modulation of basal permeability and acute inflammatory responses in rat venular microvessels.Cardiovasc Res. 2010; 88: 344-351
- Pain and inflammation after periapical surgery in 60 patients.J Oral Maxillofac Surg. 2006; 64: 429-433
- Patient discomfort following periapical surgery.Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008; 105: 245-250
- Pain and swelling after periapical surgery related to oral hygiene and smoking.Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007; 104: 271-276
Article info
Publication history
Published online: April 16, 2012
Identification
Copyright
© 2012 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
