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A Novel Polyurethane Expandable Root Canal Sealer

  • Mohammad Ali Saghiri
    Correspondence
    Address requests for reprints to Dr Mohammad Ali Saghiri, Biomaterial and Prosthodontics Laboratory, Department of Restorative Dentistry, Office: MSB C639A, Rutgers Biomedical and Health Sciences, 185 South Orange Avenue, Newark, NJ 07103.
    Affiliations
    Biomaterial and Prosthodontics Laboratory, Rutgers School of Dental Medicine, Newark, New Jersey

    Department of Restorative Dentistry, Rutgers School of Dental Medicine, Newark, New Jersey

    Department of Endodontics, University of the Pacific, Arthur A. Dugoni School of Dentistry, San Francisco, California
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  • Kasra Karamifar
    Affiliations
    Sector of Angiogenesis Regenerative Medicine, Dr. Hajar Afsar Lajevardi Research Cluster, Hackensack, New Jersey
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  • Devyani Nath
    Affiliations
    Biomaterial and Prosthodontics Laboratory, Rutgers School of Dental Medicine, Newark, New Jersey

    Department of Restorative Dentistry, Rutgers School of Dental Medicine, Newark, New Jersey
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  • James L. Gutmann
    Affiliations
    Department of Endodontics, Nova Southeastern University, College of Dental Medicine, Fort Lauderdale, Florida
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  • Nader Sheibani
    Affiliations
    McPherson Eye Research Institute, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin

    Department of Cell and Regenerative Biology, University of Wisconsin, Madison, Wisconsin

    Department of Biomedical Engineering, University of Wisconsin, Madison, Wisconsin
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Published:December 22, 2020DOI:https://doi.org/10.1016/j.joen.2020.12.007

      Abstract

      Introduction

      Endodontic sealers play a vital role in the obturation of root canal space. The aim of this study was to evaluate the utility of a recently developed polyurethane expandable sealer (PES), along with its cytotoxicity and dimensional changes.

      Methods

      L929 fibroblasts and an cell viability assay (MTS assay) were used to determine the cytotoxicity of dental sealers (AH Plus [Dentsply Maillefer, Ballaigues, Switzerland], Sure-Seal Root [Sure Dent Corporation, Gyeonggi-do, South Korea], and the PES) at 24, 48, 72, and 96 hours. An advanced choroidal neovascularization model was used to assess the effect of these sealers on angiogenesis. Thirty-six extracted single-rooted human teeth were prepared and randomly divided into 3 groups (n = 12). Obturation was performed with gutta-percha and a sealer using lateral compaction as follows: group 1, AH Plus; group 2, Sure-Seal; and group 3, PES. The average depth of sealer penetration into dentinal tubules was measured with a scanning electron microscope. Data were analyzed using 1-way analysis of variance and post hoc Tukey tests (level of significance, P < .05).

      Results

      The values of MTS, choroidal neovascularization, and the penetration depth of PES were significantly higher than in other experimental groups (P < .05). The lowest values were noted in specimens of AH Plus, whereas the highest were detected in the PES group.

      Conclusions

      PES showed promising results in terms of biocompatibility and dentinal tubule adaptation and penetration.

      Key Words

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