Abstract
Introduction
The objective of this case-control study was to investigate the association between
denosumab use and the risk of developing external cervical resorption (ECR).
Methods
Thirty-three patients ≥45 years old who were diagnosed with ECR were selected. Controls
were matched to the cases based on sex and age (±5 years) in a 1:1 ratio. Confounders
were classified into systemic factors, including a history of systemic sclerosis,
hepatitis B, denosumab use, and bisphosphonate use, or local factors, including a
history of traumatic occlusion, periodontal procedures (scaling and root planing and
periodontal surgeries), and tooth extraction (excluding third molar extraction). Additionally,
the number of remaining teeth in each subject was recorded using panoramic radiographs.
The baseline characteristics of the 2 groups, including age, sex, and the number of
remaining teeth, were compared using the chi-square and Mann-Whitney U tests. Binary logistic regression was used to determine the possible association
between denosumab use and the risk of developing ECR (α < 0.05).
Results
No significant differences in baseline characteristics were observed between the case
and control groups (P > .05). After adjusting for systemic and local cofounders, denosumab use was significantly
associated with the occurrence of ECR (odds ratio = 7.317; 95% confidence interval,
1.410–37.966; P < .05).
Conclusions
Based on the binary logistic regression model, denosumab use could significantly predict
the risk of developing ECR.
Key Words
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Article info
Publication history
Published online: December 22, 2020
Identification
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© 2020 American Association of Endodontists.
