Abstract
Introduction
This study evaluated the effects of a high-fat diet (HFD) on the progression of apical
periodontitis (AP) in rats.
Methods
Eight-week old Wistar rats (N = 24) were included in this study. Half of the animals received an HFD and the other
half a control diet (CD). AP lesions were induced 8 weeks later by creating pulp exposure
of the mandibular left first molars. The animal’s body mass was verified on a weekly
basis. After 21 and 40 days, the animals were sacrificed. Blood was collected for
biochemical tests, and the liver was removed for hepatic triglycerides analysis. The
left hemimandibles were removed, radiographed, and then prepared for histologic evaluation.
The right hemimandibles (region near molars) were removed for bone mineral density
analysis by dual-energy X-ray absorptiometry.
Results
Radiographs showed that AP lesions were significantly larger in the HFD group compared
with the CD group (P < .05). Histologic analysis confirmed that the AP lesions were larger and revealed
a more severe inflammatory infiltrate in the HFD group. Bone mineral density was reduced
in the HFD group compared with the CD groups (P < .05). The HFD resulted in a significant increase in body mass (P < .05), liver mass (P < .05), relative liver mass (P < .05), and hepatic triglycerides (P < .05). The levels of triglycerides and very–low-density lipoprotein were significantly
higher in the 40-day HFD group compared with the 21-day HFD and 21- and 40-day CD
groups (P < .05).
Conclusions
Findings suggest that an HFD can influence the progression and severity of AP.
Key Words
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Article info
Publication history
Published online: December 29, 2020
Identification
Copyright
© 2020 American Association of Endodontists.
