Abstract
Introduction
This study aimed to perform a more precise estimation of the association between tumor
necrosis factor alpha (TNF-α) −308 G/A single-nucleotide polymorphism (SNP) and the
risk of development of apical periodontitis (AP) and its phenotypes based on all available
published studies.
Methods
The study was performed according to the Preferred Reporting Items for Systematic
Reviews and Meta-Analyses guidelines and is registered in PROSPERO (CRD42020176190).
The literature search was conducted via Clarivate Analytics Web of Science, Scopus,
PubMed, Cochrane Central Register of Controlled Trials, and China National Knowledge
Infrastructure databases from inception to December 2020 with no language restrictions.
Two reviewers were involved independently in the study selection, data extraction,
and appraising the studies that were included. The quality of the included studies
was evaluated using the Strengthening the Reporting of Genetic Association and the
Grading of Recommendations Assessment, Development and Evaluation system. The frequencies
of the genotypes and alleles of the TNF-α (G>A 308, rs1800629) gene with 95% odds
ratio were used.
Results
Four studies met the inclusion criteria with moderate risk of bias. This study revealed
no significant association between TNF-α −308 G/A SNP and AP and the risk of AP development.
Moreover, there was no significant association between genotype or allele frequency
distribution and clinical manifestations (acute vs chronic) of AP. The certainty of
evidence per the Grading of Recommendations Assessment, Development and Evaluation
system was very low.
Conclusions
Because of very low certainty of evidence, whether there is an association between
TNF-α −308 G/A SNP and AP warrants further well-designed multicentric studies to adjudicate
a better understanding of the role of genetic factors in the etiopathogenesis of AP.
Key Words:
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Article info
Publication history
Published online: March 25, 2021
Identification
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© 2021 American Association of Endodontists.
