Abstract
Introduction
Maternal apical periodontitis (AP) is associated with insulin resistance (IR) in adult
offspring. Oxidative stress has been linked to IR. This study investigated insulin
sensitivity (IS) and oxidative stress in the gastrocnemius muscle (GM) of adult offspring
of rats with AP.
Methods
Fifteen female Wistar rats were distributed into a control group, a group with 1 tooth
with AP, and a group with 4 teeth with AP. Thirty days after AP induction, female
rats were mated with healthy male rats. When male offspring reached 75 days of age,
glycemia, insulinemia, and IS were determined. In the GM, the oxidative damage products
(thiobarbituric acid reactive substances and carbonyl protein) and activities of enzymatic
(superoxide dismutase, catalase, and glutathione peroxidase) and nonenzymatic (glutathione
and total antioxidant capacity) antioxidants were quantified. Analysis of variance
was performed followed by the Tukey post hoc test (P < .05).
Results
Maternal AP was associated with decreased IS and changes in antioxidant activities
(reduced superoxide dismutase and increased catalase, glutathione peroxidase, and
glutathione) and decreased thiobarbituric acid reactive substance concentration in
the GM of their adult offspring. However, maternal AP does not appear to affect glycemia,
carbonyl protein concentration, and the nonenzymatic total antioxidant capacity in
the GM of this offspring.
Conclusions
Maternal AP modulates the antioxidant defense system in the GM of their adult offspring,
attenuating lipid peroxidation in this tissue. This reflects part of an adaptive response
of the offspring to the stimulation of the maternal chronic oral inflammatory process
in which the organism acts by decreasing oxidative tissue damage in the postnatal
stage. The present study improves knowledge about the impact of maternal oral inflammation
on healthy offspring.
Key Words
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Article info
Publication history
Published online: April 14, 2021
Identification
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© 2021 American Association of Endodontists.
