Abstract
Introduction
Photoactivated chitosan-based nanoparticles can eliminate bacterial biofilm, inactivate
endotoxins, improve resistance to biological degradation (resorption), and promote
bone regeneration. This case is the first documentation to highlight the successful
healing of teeth with extensive inflammatory root resorption (IRR) with periapical
lesions using a combined surgical and nonsurgical root canal therapy using rose bengal
functionalized chitosan nanoparticles (CSRBnp).
Methods
A 17-year-old boy with extensive IRR of maxillary right canine (teeth #6), maxillary
right lateral incisor (#7), maxillary right central incisor (#8), and maxillary left
central incisor (#9) was treated with photoactivated CSRBnp, both intracanal as well
as topically on resorptive defects and periapical lesions. The larger external resorptive
defects on the root surfaces were restored with Biodentine, whereas the through-and-through
periapical lesions were packed with sticky bone for Guided Bone Regeneration.
Results
At 26 months of follow-up, the clinical, 2-dimensional (intraoral periapical radiographs)
and 3-dimensional (cone-beam computed tomography) images showed absence of clinical
symptoms, teeth mobility, arrested IRR, and significant osseous healing of the periradicular
region. Postoperatively, the patient retraumatized thrice in relation to #7 resulting
in horizontal root fracture, which showed type I pattern of root fracture healing
in the follow-up.
Conclusions
Photoactivated chitosan-based nanoparticles can be a viable therapeutic option to
hinder root resorption while enhancing healing outcomes in cases of severe IRR.
Key Words
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Article info
Publication history
Published online: April 19, 2021
Identification
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© 2021 American Association of Endodontists.
