Abstract
Introduction
The aim of this study was to assess the prevalence of reporting of confidence intervals
(CIs) in clinical trials in endodontics and discover any further associations with
a range of publication characteristics.
Methods
The electronic contents of the 3 leading endodontic journals with the highest impact
factors (International Endodontic Journal, Journal of Endodontics, and Australian Endodontic Journal) were assessed from January 2016 to December 2020. The number and proportion of clinical
trials reporting CIs for the difference in effectiveness/safety of competing interventions
for the outcome of interest were recorded. Associations with journal, year of publication,
study design, use of analyses for more complex sets of data, and others were assessed.
Univariable and multivariable logistic regressions were used to identify significant
predictor variables. Yearly linear trend effects were also sought.
Results
A total of 141 reports of clinical trials were identified. The majority were published
in the Journal of Endodontics (90/141, 63.8%) followed by the International Endodontic Journal (41/141, 29.1%). CI reporting was confirmed only for 29.1% of the sample of reports
(41/141). There was strong evidence that reports of clinical trials including analyses
of more complex sets of data presented 11.47 times higher odds for CI reporting (adjusted
odds ratio = 11.47; 95% CI, 4.19–31.41; P < .001).
Conclusions
The inclusion of uncertainty measures as represented by the reporting of CIs is suboptimal
within endodontic clinical trial reports.
Key Words
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Article info
Publication history
Published online: May 05, 2021
Identification
Copyright
© 2021 American Association of Endodontists.
