Advertisement

Biologic effects of endodontic antimicrobial agents

  • Author Footnotes
    1 Dr. Spångberg is professor of endodontics
    Larz Spångberg
    Correspondence
    Requests for reprints should be directed to Dr. Spångberg.
    Footnotes
    1 Dr. Spångberg is professor of endodontics
    Affiliations
    Farmington, Conn
    Search for articles by this author
  • Author Footnotes
    2 Dr. Rutberg is assistant clinical professor of endodontics
    Michael Rutberg
    Footnotes
    2 Dr. Rutberg is assistant clinical professor of endodontics
    Affiliations
    Farmington, Conn
    Search for articles by this author
  • Author Footnotes
    3 Dr. Rydinge is assistant professor of restorative dentistry, School of Dental Medicine, University of Connecticut Health Center, Farmington, 06032.
    Elisabeth Rydinge
    Footnotes
    3 Dr. Rydinge is assistant professor of restorative dentistry, School of Dental Medicine, University of Connecticut Health Center, Farmington, 06032.
    Affiliations
    Farmington, Conn
    Search for articles by this author
  • Author Footnotes
    1 Dr. Spångberg is professor of endodontics
    2 Dr. Rutberg is assistant clinical professor of endodontics
    3 Dr. Rydinge is assistant professor of restorative dentistry, School of Dental Medicine, University of Connecticut Health Center, Farmington, 06032.
      This paper is only available as a PDF. To read, Please Download here.
      Camphorated paramonochlorphenol, camphorated phenol, Cresatin, formocresol and iodine potassium iodide were evaluated for toxicity and tissue irritation utilizing in vitro and in vivo methodologies. In addition to the presented new data, information in existing literature was critically analyzed. Based on current and old information related to these medicaments, recommendations are made for the rational use of endodontic antiseptics.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of Endodontics
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Pear J.R.
        Bactericidal effects of some drugs used in pulp canal therapy.
        JADA. 1942; 29: 244-248
        • Wolfsohn B.L.
        Effectiveness of a group of endodontic therapeutic agents.
        Oral Surg. 1958; 11: 1394-1403
        • Spångberg L.
        • Engström B.
        Studies on root canal medicaments. IV. Antimicrobial effect of root canal medicaments.
        Odontol Rev. 1968; 19: 187-195
        • Engström B.
        • Spångberg L.V.
        vitro.
        Toxic and antimicrobial effects of antiseptics in Sven Tandlak T. 1969; 62: 543-549
        • Wesley D.J.
        • Marshall F.J.
        • Rosen S.
        The quantitation of formocresol as a root canal medicament.
        Oral Surg. 1970; 29: 603-612
        • Harrison J.W.
        • Madonia J.V.
        Antimicrobial effectiveness of parachlorphenol.
        Oral Surg. 1970; 30: 267-275
        • Lamers A.C.
        • The S.D.
        Formocresol als wortelkanaaldesinfectans.
        Nederl T Tandneelk. 1970; 77: 86-89
        • Vander Wall G.L.
        • Dowson J.
        • Shipman C.
        Antibacterial efficacy and cytotoxicity of three endodontic drug.
        Oral Surg. 1972; 33: 230-241
        • Spångberg L.
        • Engström B.
        • Langeland K.
        Biologic effects of materials. Toxicity and antimicrobial effect of endodontic antiseptics in vitro.
        Oral Surg. 1973; 36: 856-871
        • Spångberg L.
        Cellular reaction to intracanal medicaments.
        in: Grossman L.I. Fifth International Conference on Endodontics. 1973: 108
        • Martin H.
        • Lasala A.
        • Michanowicz A.
        Permeability of the apical third of the root to drugs used in endodontic therapy: an in vitro study.
        J Oral Ther. 1968; 4: 451-455
        • Treanor H.F.
        • Goldman M.
        Bactericidal efficiency of intracanal medications.
        Oral Surg. 1972; 33: 791-796
        • Buckley J.P.
        A rational treatment for putrescent pulps.
        Dent. Rev. 1904; 18: 1193-1197
        • Coolidge E.D.
        Reaction of dog tissue to drugs used in root canal treatment.
        JADA. 1932; 19: 747-759
        • Schilder H.
        • Amsterdam M.
        Inflammatory potential of root canal medicaments. A preliminary report including nonspecific drugs.
        Oral Surg. 1959; 12: 211-221
        • Torneck C.D.
        Reaction of hamster tissue to drugs used in sterilization of the root canal.
        Oral Surg. 1961; 14: 730-747
        • Straffon L.H.
        • Han S.S.
        The effect of formocresol on hamster connective tissue cells, a histologic and quantitative radioautographic study with proline-H3.
        Arch Oral Biol. 1968; 13: 271-278
        • Straffon L.H.
        • Han S.S.
        Effects of varying concentrations of formocresol on RNA synthesis of connective tissues in sponge implants.
        Oral Surg. 1970; 29: 915-925
        • Harrison J.W.
        • Madonia J.V.
        The toxicity of parachlorphenol.
        Oral Surg. 1971; 32: 90-99
        • Rutberg M.
        • Spångberg E.
        • Spångberg L.
        Evaluation of enhanced vascular permeability of endodontic medicaments in vivo.
        J Endod. 1977; 3: 347
        • Spångberg L.
        Kinetic and quantitative evaluation of material cytotoxicity in vitro.
        Oral Surg. 1973; 35: 389-401
        • Spångberg L.
        Correlation of in vivo and in vitro screening tests.
        J Endod. 1978; 10: 296-299
        • Powell D.L.
        • Marshall F.J.
        • Melfi R.C.
        A histopathologic evaluation of tissue reactions to the minimum effective doses of some endodontic drugs.
        Oral Surg. 1973; 36: 261-272
        • Engström B.
        • Spångberg L.
        Studies on root canal medicaments. 1. Cytotoxic effect of root canalantiseptics.
        Acta Odont Scand. 1967; 25: 77-84
        • Kantz W.E.
        • Ferrillo P.J.
        • Zimmermann E.R.
        Cytotoxicity of three endodontic intracanal medicaments.
        Oral Surg. 1974; 38: 600-604